Arenavirus genomics: novel insights into viral diversity, origin, and evolution.
Journal
Current opinion in virology
ISSN: 1879-6265
Titre abrégé: Curr Opin Virol
Pays: Netherlands
ID NLM: 101560941
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
07
09
2018
revised:
01
11
2018
accepted:
02
11
2018
pubmed:
30
11
2018
medline:
27
2
2020
entrez:
30
11
2018
Statut:
ppublish
Résumé
Next-generation sequencing technologies have revolutionized our knowledge of virus diversity and evolution. In the case of arenaviruses, which are the focus of this review, metagenomic/metatranscriptomic approaches identified reptile-infecting and fish-infecting viruses, also showing that bi-segmented genomes are not a universal feature of the Arenaviridae family. Novel mammarenaviruses were described, allowing inference of their geographic origin and evolutionary dynamics. Extensive sequencing of Lassa virus (LASV) genomes revealed the zoonotic nature of most human infections and a Nigerian origin of LASV, which subsequently spread westward. Future efforts will likely identify many more arenaviruses and hopefully provide insight into the ultimate origin of the family, the pathogenic potential of its members, as well as the determinants of their geographic distribution.
Identifiants
pubmed: 30497052
pii: S1879-6257(18)30103-2
doi: 10.1016/j.coviro.2018.11.001
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
18-28Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.