Dimethyl fumarate and vitamin D derivatives cooperatively enhance VDR and Nrf2 signaling in differentiating AML cells in vitro and inhibit leukemia progression in a xenograft mouse model.
Animals
Antineoplastic Agents
/ pharmacology
Cell Differentiation
/ drug effects
Cell Line, Tumor
Dimethyl Fumarate
/ pharmacology
Drug Synergism
Female
Humans
Leukemia
/ drug therapy
Leukemia, Myeloid, Acute
/ drug therapy
Mice, Inbred ICR
NF-E2-Related Factor 2
/ metabolism
Receptors, Calcitriol
/ metabolism
Signal Transduction
/ drug effects
Vitamin D
/ analogs & derivatives
Vitamins
/ chemistry
25-dihydroxyvitamin D(2)
Acute myeloid leukemia
Analogs of 1
Cell differentiation
Dimethyl fumarate
PRI-5202
Paricalcitol (PRI-5100)
Resistance to CYP24A1-mediated metabolism
Vitamin D receptor
Xenograft mouse model of AML
Journal
The Journal of steroid biochemistry and molecular biology
ISSN: 1879-1220
Titre abrégé: J Steroid Biochem Mol Biol
Pays: England
ID NLM: 9015483
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
28
09
2018
revised:
12
11
2018
accepted:
29
11
2018
pubmed:
7
12
2018
medline:
22
5
2019
entrez:
4
12
2018
Statut:
ppublish
Résumé
Acute myeloid leukemia (AML) is one of the deadliest hematological malignancies without effective treatment for most patients. Vitamin D derivatives (VDDs) - active metabolites 1α,25-dihydroxyvitamin D
Identifiants
pubmed: 30508646
pii: S0960-0760(18)30602-2
doi: 10.1016/j.jsbmb.2018.11.017
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
NF-E2-Related Factor 2
0
Receptors, Calcitriol
0
Vitamins
0
Vitamin D
1406-16-2
Dimethyl Fumarate
FO2303MNI2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
8-16Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.