Proteasome lid bridges mitochondrial stress with Cdc53/Cullin1 NEDDylation status.
26S proteasome
Mitochondria
NEDD8/Rub1
Rpn11
Thiol switch
Ubiquitin
Journal
Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
24
08
2018
revised:
11
11
2018
accepted:
15
11
2018
pubmed:
7
12
2018
medline:
22
3
2019
entrez:
4
12
2018
Statut:
ppublish
Résumé
Cycles of Cdc53/Cullin1 rubylation (a.k.a NEDDylation) protect ubiquitin-E3 SCF (Skp1-Cullin1-F-box protein) complexes from self-destruction and play an important role in mediating the ubiquitination of key protein substrates involved in cell cycle progression, development, and survival. Cul1 rubylation is balanced by the COP9 signalosome (CSN), a multi-subunit derubylase that shows 1:1 paralogy to the 26S proteasome lid. The turnover of SCF substrates and their relevance to various diseases is well studied, yet, the extent by which environmental perturbations influence Cul1 rubylation/derubylation cycles per se is still unclear. In this study, we show that the level of cellular oxidation serves as a molecular switch, determining Cullin1 rubylation/derubylation ratio. We describe a mutant of the proteasome lid subunit, Rpn11 that exhibits accumulated levels of Cullin1-Rub1 conjugates, a characteristic phenotype of csn mutants. By dissecting between distinct phenotypes of rpn11 mutants, proteasome and mitochondria dysfunction, we were able to recognize the high reactive oxygen species (ROS) production during the transition of cells into mitochondrial respiration, as a checkpoint of Cullin1 rubylation in a reversible manner. Thus, the study adds the rubylation cascade to the list of cellular pathways regulated by redox homeostasis.
Identifiants
pubmed: 30508698
pii: S2213-2317(18)30760-2
doi: 10.1016/j.redox.2018.11.010
pmc: PMC6279957
pii:
doi:
Substances chimiques
Cullin 1
0
Cullin Proteins
0
Reactive Oxygen Species
0
Proteasome Endopeptidase Complex
EC 3.4.25.1
Ubiquitin-Activating Enzymes
EC 6.2.1.45
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
533-543Subventions
Organisme : NIDA NIH HHS
ID : K05 DA000064
Pays : United States
Informations de copyright
Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.
Références
Cell. 2011 Nov 23;147(5):1024-39
pubmed: 22118460
Redox Biol. 2017 Apr;11:613-619
pubmed: 28110218
Annu Rev Biochem. 2009;78:477-513
pubmed: 19489727
Nature. 2009 Apr 9;458(7239):732-6
pubmed: 19360080
Cell Rep. 2014 Jun 12;7(5):1371-1380
pubmed: 24857655
J Biol Chem. 2017 Mar 3;292(9):3854-3865
pubmed: 28096463
PLoS One. 2012;7(8):e43980
pubmed: 22956996
Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1763-70
pubmed: 21209336
Cell. 1998 Sep 4;94(5):615-23
pubmed: 9741626
FEMS Yeast Res. 2004 Nov;5(2):149-56
pubmed: 15489198
Plant Sci. 2013 Apr;203-204:89-97
pubmed: 23415332
Mol Cell Proteomics. 2014 Oct;13(10):2573-83
pubmed: 24973421
Nucleic Acids Res. 2003 Jul 15;31(14):3909-17
pubmed: 12853606
ACS Cent Sci. 2018 Feb 28;4(2):246-259
pubmed: 29532025
Mol Cell. 2009 Aug 14;35(3):260-4
pubmed: 19683491
FEBS Lett. 1997 Jun 30;410(2-3):219-22
pubmed: 9237633
EMBO J. 2009 Sep 16;28(18):2748-62
pubmed: 19680224
EMBO J. 1998 Sep 1;17(17):4909-19
pubmed: 9724628
PLoS One. 2016 Jan 25;11(1):e0147991
pubmed: 26808496
Genes Dev. 1998 Apr 1;12(7):914-26
pubmed: 9531531
Chem Rev. 2018 Feb 14;118(3):889-918
pubmed: 28234446
J Biol Chem. 2013 Mar 22;288(12):8136-45
pubmed: 23362276
EMBO Rep. 2013 Dec;14(12):1050-61
pubmed: 24232186
Biosci Rep. 2015 Jan 27;35(3):null
pubmed: 26182356
Curr Pharm Des. 2013;19(18):3215-25
pubmed: 23151137
Nat Methods. 2011 Oct 02;8(11):937-40
pubmed: 21963607
Gene. 2002 Mar 6;286(1):43-51
pubmed: 11943459
Antioxid Redox Signal. 2018 Mar 1;28(7):537-557
pubmed: 28587524
Nat Commun. 2013;4:1641
pubmed: 23535662
Mol Aspects Med. 2018 Oct;63:3-17
pubmed: 30059710
Biotechnol Biofuels. 2010 Jan 15;3:2
pubmed: 20150993
Nat Cell Biol. 2005 Apr;7(4):387-91
pubmed: 15793566
Genes Dev. 1998 Mar 1;12(5):692-705
pubmed: 9499404
Mol Biol Cell. 2008 Mar;19(3):1022-31
pubmed: 18172023
Mol Cell. 2018 Jan 18;69(2):203-213
pubmed: 29351842
Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16419-24
pubmed: 15534200
FASEB J. 1998 May;12(7):561-9
pubmed: 9576483
Curr Genet. 1992 Jan;21(1):83-4
pubmed: 1735128
EMBO J. 2016 Jun 15;35(12):1312-29
pubmed: 27174643
Nat Struct Mol Biol. 2008 Jun;15(6):573-80
pubmed: 18511945
Nat Rev Mol Cell Biol. 2009 May;10(5):319-31
pubmed: 19352404
Antioxid Redox Signal. 2011 Mar 15;14(6):1049-63
pubmed: 20626317
Curr Biol. 2003 Jul 1;13(13):1140-4
pubmed: 12842014
J Biol Chem. 2011 Jun 10;286(23):20267-74
pubmed: 21515692
EMBO Rep. 2002 Dec;3(12):1215-21
pubmed: 12446563
Mol Cell. 2002 Feb;9(2):387-99
pubmed: 11864611
Nature. 2014 Aug 14;512(7513):161-5
pubmed: 25043011
Nat Struct Mol Biol. 2004 Oct;11(10):927-35
pubmed: 15361859
J Biol Chem. 1998 Dec 25;273(52):34983-91
pubmed: 9857030
Nucleic Acids Res. 2016 Jul 8;44(W1):W83-9
pubmed: 27098042
Clin Cancer Res. 2009 Jun 15;15(12):3912-6
pubmed: 19509147
Elife. 2016 Mar 31;5:
pubmed: 27031283
Curr Genet. 2018 Aug 18;:null
pubmed: 30121730
Annu Rev Plant Biol. 2004;55:555-90
pubmed: 15377232
J Cell Physiol. 2013 Nov;228(11):2190-201
pubmed: 23589227
PLoS Biol. 2004 Jan;2(1):E2
pubmed: 14737182
Science. 2002 Oct 18;298(5593):608-11
pubmed: 12183637
Mol Cell. 2011 Aug 5;43(3):488-95
pubmed: 21816351
EMBO J. 2003 Oct 15;22(20):5501-10
pubmed: 14532122
Electrophoresis. 1997 Mar-Apr;18(3-4):409-17
pubmed: 9150919
Science. 2002 Oct 18;298(5593):611-5
pubmed: 12183636
Cell. 2005 Mar 11;120(5):649-61
pubmed: 15766528
Biochem J. 2012 Feb 1;441(3):927-36
pubmed: 22004789
Endocr Relat Cancer. 2015 Feb;22(1):T55-70
pubmed: 25504797
Nature. 2002 Sep 26;419(6905):403-7
pubmed: 12353037
J Biol Chem. 1997 Sep 12;272(37):23086-93
pubmed: 9287309
Nat Struct Mol Biol. 2011 Jul 17;18(8):947-9
pubmed: 21765416
Int J Microbiol. 2017;2017:5792192
pubmed: 28154578
Biochemistry. 2002 Feb 19;41(7):2184-90
pubmed: 11841209
FEBS Lett. 2015 Sep 14;589(19 Pt A):2507-13
pubmed: 26096786
Nature. 2016 Mar 31;531(7596):598-603
pubmed: 27029275
Nat Rev Mol Cell Biol. 2015 Jan;16(1):30-44
pubmed: 25531226
Genes Dev. 1999 Jun 15;13(12):1614-26
pubmed: 10385629
Front Mol Neurosci. 2017 Jun 06;10:167
pubmed: 28634440
Biochim Biophys Acta. 2014 Aug;1844(8):1335-43
pubmed: 24657586
Curr Genet. 2001 May;39(3):137-49
pubmed: 11409175
BMC Biol. 2014 Nov 11;12:94
pubmed: 25385277
Mol Cell Biol. 2012 Nov;32(21):4472-81
pubmed: 22949505
Nature. 2009 Mar 26;458(7237):422-9
pubmed: 19325621
Mol Cell. 2006 Feb 3;21(3):349-57
pubmed: 16455490
Int J Biochem Cell Biol. 2003 May;35(5):706-15
pubmed: 12672462
Biochem Biophys Res Commun. 2010 Jun 11;396(4):1048-53
pubmed: 20471955
Nat Rev Drug Discov. 2009 Jul;8(7):579-91
pubmed: 19478820
Mol Biol Cell. 2005 May;16(5):2503-17
pubmed: 15758028
Mol Biol Cell. 2011 Apr;22(7):911-20
pubmed: 21289098
Science. 2001 May 18;292(5520):1382-5
pubmed: 11337588
Mol Cells. 1998 Oct 31;8(5):503-12
pubmed: 9856335
Methods. 2011 Aug;54(4):379-86
pubmed: 21440633
J Enzyme Inhib Med Chem. 2016 Dec;31(6):1632-7
pubmed: 27028668
J Biol Chem. 2008 Mar 14;283(11):7166-75
pubmed: 18174173
Mol Cell Biol. 2006 Jul;26(13):4818-29
pubmed: 16782871
Physiol Rev. 2002 Apr;82(2):373-428
pubmed: 11917093
Mol Biol Cell. 1998 Oct;9(10):2917-31
pubmed: 9763452
Cell Cycle. 2011 Sep 15;10(18):3057-66
pubmed: 21876386
Biochem J. 2004 Jul 1;381(Pt 1):275-85
pubmed: 15018611
Trends Biochem Sci. 2008 Dec;33(12):592-600
pubmed: 18926707
BMC Biochem. 2002 Sep 20;3:28
pubmed: 12370088
Curr Genet. 2017 Feb;63(1):1-7
pubmed: 27180089