Spatial Determination of Neuronal Diversification in the Olfactory Epithelium.
Animals
Cell Differentiation
/ physiology
Cues
Epigenesis, Genetic
Female
Male
Mice
Mice, Inbred C57BL
Neural Cell Adhesion Molecules
/ biosynthesis
Neural Stem Cells
Neurogenesis
/ physiology
Neuronal Plasticity
Olfactory Mucosa
/ cytology
Olfactory Receptor Neurons
/ physiology
Stem Cell Transplantation
olfactory epithelium
plasticity
regeneration
spatial determination
transplantation
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
30 01 2019
30 01 2019
Historique:
received:
21
12
2017
revised:
21
11
2018
accepted:
23
11
2018
pubmed:
12
12
2018
medline:
18
12
2019
entrez:
12
12
2018
Statut:
ppublish
Résumé
Neurons in the murine olfactory epithelium (OE) differ by the olfactory receptor they express as well as other molecular phenotypes that are regionally restricted. These patterns can be precisely regenerated following epithelial injury, suggesting that spatial cues within the tissue can direct neuronal diversification. Nonetheless, the permanency and mechanism of this spatial patterning remain subject to debate. Via transplantation of stem and progenitor cells from dorsal OE into ventral OE, we demonstrate that, in mice of both sexes, nonautonomous spatial cues can direct the spatially circumscribed differentiation of olfactory sensory neurons. The vast majority of dorsal transplant-derived neurons express the ventral marker OCAM (NCAM2) and lose expression of NQO1 to match their new location. Single-cell analysis also demonstrates that OSNs adopt a fate defined by their new position following progenitor cell transplant, such that a ventral olfactory receptor is expressed after stem and progenitor cell engraftment. Thus, spatially constrained differentiation of olfactory sensory neurons is plastic, and any bias toward an epigenetic memory of place can be overcome.
Identifiants
pubmed: 30530861
pii: JNEUROSCI.3594-17.2018
doi: 10.1523/JNEUROSCI.3594-17.2018
pmc: PMC6382982
doi:
Substances chimiques
Ncam2 protein, mouse
0
Neural Cell Adhesion Molecules
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
814-832Subventions
Organisme : NIDCD NIH HHS
ID : F31 DC014398
Pays : United States
Organisme : NIDCD NIH HHS
ID : F31 DC014637
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC002167
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC006267
Pays : United States
Informations de copyright
Copyright © 2019 the authors 0270-6474/19/390814-19$15.00/0.
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