Genetically Informative Mediation Modeling Applied to Stressors and Personality-Disorder Traits in Etiology of Alcohol Use Disorder.
Adult
Adverse Childhood Experiences
Alcoholism
/ etiology
Biometry
Child
Diagnostic and Statistical Manual of Mental Disorders
Diseases in Twins
Female
Gene-Environment Interaction
Humans
Life Change Events
Male
Models, Statistical
Norway
Personality
Personality Disorders
/ complications
Phenotype
Risk Factors
Twins
/ genetics
Antisocial personality disorder
Borderline personality disorder
Causality
Statistical mediation model
Stressful life events
Substance use
Twin study
Journal
Behavior genetics
ISSN: 1573-3297
Titre abrégé: Behav Genet
Pays: United States
ID NLM: 0251711
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
25
01
2018
accepted:
27
11
2018
pubmed:
12
12
2018
medline:
17
4
2019
entrez:
12
12
2018
Statut:
ppublish
Résumé
A statistical mediation model was developed within a twin design to investigate the etiology of alcohol use disorder (AUD). Unlike conventional statistical mediation models, this biometric mediation model can detect unobserved confounding. Using a sample of 1410 pairs of Norwegian twins, we investigated specific hypotheses that DSM-IV personality-disorder (PD) traits mediate effects of childhood stressful life events (SLEs) on AUD, and that adulthood SLEs mediate effects of PDs on AUD. Models including borderline PD traits indicated unobserved confounding in phenotypic path coefficients, whereas models including antisocial and impulsive traits did not. More than half of the observed effects of childhood SLEs on adulthood AUD were mediated by adulthood antisocial and impulsive traits. Effects of PD traits on AUD 5‒10 years later were direct rather than mediated by adulthood SLEs. The results and the general approach contribute to triangulation of developmental origins for complex behavioral disorders.
Identifiants
pubmed: 30536213
doi: 10.1007/s10519-018-9941-z
pii: 10.1007/s10519-018-9941-z
pmc: PMC6377430
mid: NIHMS1516219
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
11-23Subventions
Organisme : NIDA NIH HHS
ID : R01 DA037558
Pays : United States
Organisme : NIDA NIH HHS
ID : 1R01DA037558-01A1
Pays : United States
Références
Psychol Rev. 2001 Apr;108(2):346-69
pubmed: 11381833
Nature. 1985 Apr 25-May 1;314(6013):734-6
pubmed: 4039415
Psychol Med. 2007 May;37(5):615-26
pubmed: 17176502
Behav Genet. 2013 Jul;43(4):314-28
pubmed: 23519636
Soc Psychiatry Psychiatr Epidemiol. 1998 Nov;33(11):568-78
pubmed: 9803825
Addiction. 2014 Nov;109(11):1824-32
pubmed: 24845951
Perspect Psychol Sci. 2010 Sep;5(5):546-56
pubmed: 21593989
Behav Genet. 2004 Nov;34(6):593-610
pubmed: 15520516
Biometrics. 1993 Jun;49(2):557-68
pubmed: 8369388
Psychol Methods. 2012 Dec;17(4):642-64
pubmed: 22905648
Psychol Methods. 2010 Dec;15(4):309-34
pubmed: 20954780
Stat Methods Med Res. 2007 Aug;16(4):309-30
pubmed: 17715159
Twin Res Hum Genet. 2013 Feb;16(1):285-95
pubmed: 23186607
Prev Sci. 2000 Dec;1(4):173-81
pubmed: 11523746
JAMA Psychiatry. 2013 Nov;70(11):1206-14
pubmed: 24048243
Twin Res. 2003 Jun;6(3):235-9
pubmed: 12855073
Behav Genet. 1993 Jan;23(1):29-50
pubmed: 8476389
Proc R Soc Med. 1965 May;58:295-300
pubmed: 14283879
Psychol Methods. 2012 Jun;17(2):228-43
pubmed: 22309957
Addiction. 2018 Jan;113(1):15-24
pubmed: 28734091
Int J Epidemiol. 2016 Dec 1;45(6):1866-1886
pubmed: 28108528
Annu Rev Psychol. 2014;65:515-40
pubmed: 24050184
J Abnorm Psychol. 2004 Feb;113(1):44-55
pubmed: 14992656
Psychometrika. 2016 Jun;81(2):535-49
pubmed: 25622929
Psychol Med. 2015 Jul;45(9):1955-64
pubmed: 25600066
Biol Psychiatry. 2012 Feb 1;71(3):247-53
pubmed: 21762879
Psychol Med. 2015 Oct;45(14):3121-31
pubmed: 26050739
Drug Alcohol Depend. 2017 May 1;174:171-180
pubmed: 28334662
J Pers Soc Psychol. 1986 Dec;51(6):1173-82
pubmed: 3806354
Annu Rev Psychol. 2015 Jan 3;66:825-52
pubmed: 25148853
J Pers. 2008 Dec;76(6):1485-522
pubmed: 19012656
J Affect Disord. 2017 Mar 01;210:82-89
pubmed: 28024223
Multivariate Behav Res. 2016 Sep-Oct;51(5):681-697
pubmed: 27739903
J Psychiatr Res. 2011 Jun;45(6):814-22
pubmed: 21146190
Stress. 2016;19(2):235-47
pubmed: 27023221
Alcohol Clin Exp Res. 2011 Jan;35(1):140-55
pubmed: 21039636
Am J Psychiatry. 2016 Sep 1;173(9):903-10
pubmed: 27056607
Psychon Bull Rev. 2004 Feb;11(1):192-6
pubmed: 15117008
Genet Epidemiol. 1994;11(6):483-502
pubmed: 7713391
Behav Genet. 2016 Jul;46(4):552-72
pubmed: 26833465
Stat Med. 2008 Apr 15;27(8):1133-63
pubmed: 17886233
Behav Genet. 1997 Mar;27(2):113-20
pubmed: 9145549
Addiction. 2018 Jan;113(1):25-33
pubmed: 28734057
Schizophr Bull. 2017 May 1;43(3):644-653
pubmed: 27431873
Twin Res Hum Genet. 2009 Apr;12(2):158-68
pubmed: 19335186
Alcohol Clin Exp Res. 2014 Jul;38(7):2048-55
pubmed: 24961735
Arch Gen Psychiatry. 2008 Dec;65(12):1438-46
pubmed: 19047531
Int J Epidemiol. 2005 Oct;34(5):1089-99
pubmed: 16087687
Drug Alcohol Depend. 2014 Sep 1;142:154-60
pubmed: 25001278
J Pers Disord. 2010 Aug;24(4):412-26
pubmed: 20695803
J Abnorm Psychol. 2016 Jul;125(5):727-45
pubmed: 27254487
Biol Psychiatry. 2017 Aug 15;82(4):275-282
pubmed: 26971049
J Pers Disord. 2014 Feb;28(1):5-18
pubmed: 24344883
Behav Genet. 2017 May;47(3):265-277
pubmed: 28108863
J Abnorm Psychol. 2017 Aug;126(6):812-822
pubmed: 28541064
J Abnorm Psychol. 2013 Feb;122(1):180-94
pubmed: 22686871
Twin Res. 2004 Oct;7(5):505-12
pubmed: 15527666
Compr Psychiatry. 2009 Jul-Aug;50(4):307-14
pubmed: 19486728
Behav Genet. 1998 Sep;28(5):357-63
pubmed: 9926617
Psychopharmacology (Berl). 2011 Nov;218(1):1-17
pubmed: 21373787