HMGB1
CX3CR1
HMGB1
Microparticles
Monocyte subsets
Systemic lupus erythematosus
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
09
06
2018
revised:
20
11
2018
accepted:
07
12
2018
pubmed:
12
12
2018
medline:
20
5
2020
entrez:
12
12
2018
Statut:
ppublish
Résumé
Non-classical monocytes infiltrate the kidney parenchyma and participate in tissue damage in patients with lupus nephritis (LN). Circulating microparticles (MPs) seem to play critical roles in the activation of monocytes in systemic lupus erythematosus (SLE) patients. This study aims to characterize the phenotypes of MPs and monocyte subsets in LN patients and to determine their potential to discriminate between SLE patients with and without LN. Blood and urine samples from SLE patients were collected. In monocyte subsets from whole blood samples several phenotypic markers were evaluated. MPs were isolated from platelet-poor plasma and urine by centrifugation. This phenotypic marker characterization was performed using multiparametric flow cytometry. We observed that patients with active LN have lower counts of non-classical monocytes than do those without renal involvement. All monocyte subsets exhibited lower expression of CX3CR1 and ICAM-1 in LN than in patients without LN. High frequencies of MP-HMGB1
Identifiants
pubmed: 30537116
doi: 10.1002/eji.201847747
doi:
Substances chimiques
Biomarkers
0
CX3C Chemokine Receptor 1
0
CX3CR1 protein, human
0
HLA-DR Antigens
0
HMGB1 Protein
0
HMGB1 protein, human
0
Intercellular Adhesion Molecule-1
126547-89-5
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
323-335Informations de copyright
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.