Cytomegalovirus Exposure in the Elderly Does Not Reduce CD8 T Cell Repertoire Diversity.
Aged
Aged, 80 and over
Aging
/ physiology
CD8-Positive T-Lymphocytes
/ immunology
Cell Proliferation
Cellular Senescence
Clonal Selection, Antigen-Mediated
Clone Cells
Cohort Studies
Cytomegalovirus
/ immunology
Cytomegalovirus Infections
/ immunology
Genes, T-Cell Receptor beta
/ genetics
Humans
Immune Tolerance
T-Lymphocytes, Cytotoxic
/ immunology
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
15 01 2019
15 01 2019
Historique:
received:
15
02
2018
accepted:
04
11
2018
pubmed:
14
12
2018
medline:
29
10
2019
entrez:
14
12
2018
Statut:
ppublish
Résumé
With age, the immune system becomes less effective, causing increased susceptibility to infection. Chronic CMV infection further impairs immune function and is associated with increased mortality in the elderly. CMV exposure elicits massive CD8
Identifiants
pubmed: 30541882
pii: jimmunol.1800217
doi: 10.4049/jimmunol.1800217
pmc: PMC6321841
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
476-483Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM007266
Pays : United States
Informations de copyright
Copyright © 2019 The Authors.
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