Characterization of sulfated polysaccharide from Laurencia obtusa and its apoptotic, gastroprotective and antioxidant activities.
Animals
Antioxidants
/ pharmacology
Apoptosis
/ drug effects
Female
Free Radical Scavengers
/ pharmacology
Humans
Laurencia
/ chemistry
Light
Magnetic Resonance Spectroscopy
Male
Malondialdehyde
/ metabolism
Oxidation-Reduction
Polysaccharides
/ pharmacology
Protective Agents
/ pharmacology
Rats, Wistar
Refractometry
Scattering, Radiation
Stomach
/ drug effects
Stomach Ulcer
/ drug therapy
Sulfates
/ pharmacology
THP-1 Cells
Toxicity Tests, Acute
Antioxidant
Apoptotic activity
Gastroprotective activity
Laurencia obtusa
Sulfated polysaccharide
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
01 Apr 2019
01 Apr 2019
Historique:
received:
12
06
2018
revised:
08
12
2018
accepted:
09
12
2018
pubmed:
14
12
2018
medline:
1
6
2019
entrez:
14
12
2018
Statut:
ppublish
Résumé
This study was designed to characterize the physico-chemical properties of the sulfated polysaccharide (SP) isolated from the red alga Laurencia obtusa and to evaluate its apoptotic, gastroprotective and antioxidant activities. The different macromolecular characteristics of SP were determined by size exclusion chromatography combined with multi-angle laser light-scattering detection (SEC-MALLS), Fourier transform infrared spectroscopy (FTIR) analysis and nuclear magnetic resonance spectroscopy (
Identifiants
pubmed: 30543883
pii: S0141-8130(18)32909-X
doi: 10.1016/j.ijbiomac.2018.12.089
pii:
doi:
Substances chimiques
Antioxidants
0
Free Radical Scavengers
0
Polysaccharides
0
Protective Agents
0
Sulfates
0
Malondialdehyde
4Y8F71G49Q
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
326-336Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.