Zengye decoction induces alterations to metabolically active gut microbiota in aged constipated rats.
Amino Acids
/ metabolism
Animals
Constipation
/ drug therapy
Drugs, Chinese Herbal
/ pharmacology
Gastrointestinal Microbiome
/ drug effects
Glutathione
/ metabolism
Male
Medicine, Chinese Traditional
/ methods
Proton Magnetic Resonance Spectroscopy
/ methods
RNA, Ribosomal, 16S
/ metabolism
Rats
Rats, Sprague-Dawley
16s rRNA
Constipation
Gut microbiome
Metabolism
Zengye decoction
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
10
10
2018
revised:
02
11
2018
accepted:
02
11
2018
entrez:
16
12
2018
pubmed:
16
12
2018
medline:
29
3
2019
Statut:
ppublish
Résumé
Zengye decoction (ZYD), a traditional Chinese medicinal formula, has been used in the treatment of various chronic diseases, such as constipation and skin dryness syndrome. Clinically, the specific mechanisms and targets of ZYD for treating disease remain unclear. The present study was undertaken to investigate the effects of ZYD on the gut microbiota and host metabolites in aged constipated rats and the relationship between the intestinal microbiota and the host. Rats were divided randomly into three groups, the control group (n = 10), recovery group (n = 10) and ZYD group (n = 10). First, the aged constipation model was established for the ZYD group and recovery group. Then, rats in the ZYD group were treated with ZYD. Urinary and faecal samples of each animal were collected in microcentrifuge tubes. Next, 16s rRNA gene sequencing was employed to analyse the composition of the gut microbiome in faecal samples and afterwards the metabolic function of the altered gut microbiota was predicted. Additionally,
Identifiants
pubmed: 30551387
pii: S0753-3322(18)37177-4
doi: 10.1016/j.biopha.2018.11.013
pii:
doi:
Substances chimiques
Amino Acids
0
Drugs, Chinese Herbal
0
RNA, Ribosomal, 16S
0
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1361-1371Informations de copyright
Copyright © 2018 The Authors. Published by Elsevier Masson SAS.. All rights reserved.