Selenols: a new class of carbonic anhydrase inhibitors.
Antigens, Neoplasm
/ chemistry
Binding Sites
Carbonic Anhydrase I
/ antagonists & inhibitors
Carbonic Anhydrase II
/ antagonists & inhibitors
Carbonic Anhydrase IX
/ antagonists & inhibitors
Carbonic Anhydrase Inhibitors
/ chemical synthesis
Carbonic Anhydrases
/ chemistry
Humans
Isoenzymes
/ antagonists & inhibitors
Molecular Docking Simulation
Molecular Structure
Organoselenium Compounds
/ chemical synthesis
Journal
Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838
Informations de publication
Date de publication:
10 Jan 2019
10 Jan 2019
Historique:
pubmed:
19
12
2018
medline:
15
2
2019
entrez:
19
12
2018
Statut:
ppublish
Résumé
Stable aryl selenols were obtained through a convenient procedure. Selenols represent a new chemotype acting as carbonic anhydrase inhibitors (CAIs), inhibiting four human isoforms, CAs I, II, VII and the tumor-associated CA IX. X-ray crystallographic, physical and computational studies provided insights into the binding mode of this conceptually new class of CAIs.
Substances chimiques
Antigens, Neoplasm
0
Carbonic Anhydrase Inhibitors
0
Isoenzymes
0
Organoselenium Compounds
0
Carbonic Anhydrase I
EC 4.2.1.-
Carbonic Anhydrase II
EC 4.2.1.-
CA1 carbonic anhydrase, human
EC 4.2.1.1
CA9 protein, human
EC 4.2.1.1
Carbonic Anhydrase IX
EC 4.2.1.1
Carbonic Anhydrases
EC 4.2.1.1
carbonic anhydrase VI
EC 4.2.1.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM