Effect of Rifampicin on the Pharmacokinetics of a Single Dose of Vemurafenib in Patients With BRAF

Adult Aged Aged, 80 and over Cytochrome P-450 CYP3A / metabolism Drug Administration Schedule Drug Interactions Female Humans Male Middle Aged Mutation Neoplasms / drug therapy Proto-Oncogene Proteins B-raf / genetics Rifampin / administration & dosage Vemurafenib / administration & dosage
CYP3A4 inducer drug-drug interactions pharmacokinetics rifampicin vemurafenib

Journal

Clinical pharmacology in drug development
ISSN: 2160-7648
Titre abrégé: Clin Pharmacol Drug Dev
Pays: United States
ID NLM: 101572899

Informations de publication

Date de publication:
08 2019
Historique:
received: 20 06 2018
accepted: 28 11 2018
pubmed: 21 12 2018
medline: 28 7 2020
entrez: 21 12 2018
Statut: ppublish

Résumé

Vemurafenib prolongs survival in patients with BRAF

Identifiants

DOI: 10.1002/cpdd.643 PMID: 30570831
pubmed: 30570831
doi: 10.1002/cpdd.643
doi:

Substances chimiques

Vemurafenib 207SMY3FQT
Cytochrome P-450 CYP3A EC 1.14.14.1
CYP3A4 protein, human EC 1.14.14.55
BRAF protein, human EC 2.7.11.1
Proto-Oncogene Proteins B-raf EC 2.7.11.1
Rifampin VJT6J7R4TR

Types de publication

Clinical Trial, Phase I Journal Article Multicenter Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

837-843

Informations de copyright

© 2018, The American College of Clinical Pharmacology.

Auteurs

Weijiang Zhang (W)

F. Hoffmann-La Roche, Ltd., New York, NY, USA.

Christine McIntyre (C)

Roche Products Ltd, Welwyn Garden City, UK.

Harper Forbes (H)

Hoffmann-La Roche Ltd, Mississauga, ON, Canada.

Rabab Gaafar (R)

National Cancer Institute, Cairo University, Cairo, Egypt.

Hanaa Kohail (H)

Medical Research Institute, Alexandria University, Alexandria, Egypt.

J Thaddeus Beck (JT)

Highlands Oncology Group, Fayetteville, AR, USA.

Stjepko Plestina (S)

School of Medicine and University Hospital Centre Zagreb, Zagreb, Croatia.

Enric Bertran (E)

Genentech, Inc., South San Francisco, CA, USA.

Todd Riehl (T)

Genentech, Inc., South San Francisco, CA, USA.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Effect of Rifampicin on the Pharmacokinetics...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Effect of Rifampicin on the Pharmacokinetics...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Effect of Rifampicin on the Pharmacokinetics...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Famille-3 de cytochromes P450 › Cytochrome P-450 CYP3A › Effect of Rifampicin on the Pharmacokinetics...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Calendrier d'administration des médicaments › Effect of Rifampicin on the Pharmacokinetics...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Interactions médicamenteuses › Effect of Rifampicin on the Pharmacokinetics...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Effect of Rifampicin on the Pharmacokinetics...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Effect of Rifampicin on the Pharmacokinetics...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Effect of Rifampicin on the Pharmacokinetics...
questionsmedicales.fr › Tumeurs › Effect of Rifampicin on the Pharmacokinetics...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Kinases raf › Protéines proto-oncogènes B-raf › Effect of Rifampicin on the Pharmacokinetics...
questionsmedicales.fr › Composés polycycliques › Composés macrocycliques › Lactames macrocycliques › Rifamycine › Rifampicine › Effect of Rifampicin on the Pharmacokinetics...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Vémurafénib › Effect of Rifampicin on the Pharmacokinetics...