Interaction of statins with phospholipid bilayers studied by solid-state NMR spectroscopy.
(1)H NMR
Intermolecular cross-relaxation
Nuclear Overhauser enhancement spectroscopy
Phospholipid membranes
Statins
Journal
Biochimica et biophysica acta. Biomembranes
ISSN: 1879-2642
Titre abrégé: Biochim Biophys Acta Biomembr
Pays: Netherlands
ID NLM: 101731713
Informations de publication
Date de publication:
01 03 2019
01 03 2019
Historique:
received:
20
07
2018
revised:
23
11
2018
accepted:
18
12
2018
pubmed:
24
12
2018
medline:
5
11
2019
entrez:
23
12
2018
Statut:
ppublish
Résumé
Statins are drugs that specifically inhibit the enzyme HMG-CoA reductase and thereby reduce the concentration of low-density lipoprotein cholesterol, which represents a well-established risk factor for the development of atherosclerosis. The results of several clinical trials have shown that there are important intermolecular differences responsible for the broader pharmacologic actions of statins, even beyond HMG-CoA reductase inhibition. According to one hypothesis, the biological effects exerted by these compounds depend on their localization in the cellular membrane. The aim of the current work was to study the interactions of different statins with phospholipid membranes and to investigate their influence on the membrane structure and dynamics using various solid-state NMR techniques. Using
Identifiants
pubmed: 30578770
pii: S0005-2736(18)30363-8
doi: 10.1016/j.bbamem.2018.12.013
pii:
doi:
Substances chimiques
Hydroxymethylglutaryl-CoA Reductase Inhibitors
0
Lipid Bilayers
0
Phosphatidylcholines
0
Phospholipids
0
Fluvastatin
4L066368AS
Lovastatin
9LHU78OQFD
Simvastatin
AGG2FN16EV
Pravastatin
KXO2KT9N0G
1-palmitoyl-2-oleoylphosphatidylcholine
TE895536Y5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
584-593Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.