Effect of cyclodextrin and cosolvent on the solubility and antioxidant activity of caffeic acid.

Antioxidants / chemistry Caffeic Acids / chemistry Cyclodextrins / chemistry Ethanol / chemistry Magnetic Resonance Spectroscopy Solubility Solvents / chemistry Water / chemistry
Antioxidant Caffeic acid Cosolvent Cyclodextrin Ethanol NMR Solubility

Journal

Food chemistry
ISSN: 1873-7072
Titre abrégé: Food Chem
Pays: England
ID NLM: 7702639

Informations de publication

Date de publication:
25 Apr 2019
Historique:
received: 31 08 2018
revised: 07 11 2018
accepted: 09 11 2018
entrez: 26 12 2018
pubmed: 26 12 2018
medline: 12 2 2019
Statut: ppublish

Résumé

Caffeic acid is a natural phenylpropanoid that exhibits various health benefits. However, it suffers from a poor aqueous solubility limiting its application. This drawback could be overcome by complexation in cyclodextrins (CD) or cosolvency. Herein, we investigated, for the first time, the combined effect of CD and ethanol as cosolvent on complexation, solubilization and antioxidant activity of caffeic acid. Results showed that CD, ethanol and their combined use enhanced the solubility of this phenylpropanoid. However, the presence of ethanol affects the formation of inclusion complexes as lower formation constants (K

Identifiants

DOI: 10.1016/j.foodchem.2018.11.055 PMID: 30583356
pubmed: 30583356
pii: S0308-8146(18)31993-9
doi: 10.1016/j.foodchem.2018.11.055
pii:
doi:

Substances chimiques

Antioxidants 0
Caffeic Acids 0
Cyclodextrins 0
Solvents 0
Water 059QF0KO0R
Ethanol 3K9958V90M
caffeic acid U2S3A33KVM

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

163-169

Informations de copyright

Copyright © 2018 Elsevier Ltd. All rights reserved.

Auteurs

Miriana Kfoury (M)

Bioactive Molecules Research Laboratory, Doctoral School of Sciences and Technologies, Faculty of Sciences, Lebanese University, Fanar, Lebanon.

Chantal Geagea (C)

Bioactive Molecules Research Laboratory, Doctoral School of Sciences and Technologies, Faculty of Sciences, Lebanese University, Fanar, Lebanon.

Steven Ruellan (S)

Unité de Chimie Environnementale et Interactions sur le Vivant (UCEIV), EA 4492 SFR Condorcet FR CNRS 3417, Université du Littoral-Côte d'Opale (ULCO), Dunkerque, France.

Hélène Greige-Gerges (H)

Bioactive Molecules Research Laboratory, Doctoral School of Sciences and Technologies, Faculty of Sciences, Lebanese University, Fanar, Lebanon.

Sophie Fourmentin (S)

Unité de Chimie Environnementale et Interactions sur le Vivant (UCEIV), EA 4492 SFR Condorcet FR CNRS 3417, Université du Littoral-Côte d'Opale (ULCO), Dunkerque, France. Electronic address: lamotte@univ-littoral.fr.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Effect of cyclodextrin and cosolvent on the...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides carbocycliques › Cinnamates › Acides caféiques › Effect of cyclodextrin and cosolvent on the...
questionsmedicales.fr › Glucides › Polyosides › Glucanes › Amidon › Dextrine › Cyclodextrines › Effect of cyclodextrin and cosolvent on the...
questionsmedicales.fr › Composés chimiques organiques › Alcools › Éthanol › Effect of cyclodextrin and cosolvent on the...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Effect of cyclodextrin and cosolvent on the...
questionsmedicales.fr › Phénomènes chimiques › Solubilité › Effect of cyclodextrin and cosolvent on the...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Solvants › Effect of cyclodextrin and cosolvent on the...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Eau › Effect of cyclodextrin and cosolvent on the...