Altered Expression of PYCARD, Interleukin 1β, Interleukin 18, and NAIP in Successfully Treated HIV-Positive Patients With a Low Ratio of CD4+ to CD8+ T Cells.
Adult
Aged
CARD Signaling Adaptor Proteins
/ genetics
CD4-Positive T-Lymphocytes
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
Female
Gene Expression Regulation
HIV Infections
/ immunology
HIV Seropositivity
Humans
Inflammasomes
/ immunology
Interleukin-18
/ genetics
Interleukin-1beta
/ genetics
Male
Middle Aged
Monocytes
/ immunology
Neuronal Apoptosis-Inhibitory Protein
/ genetics
AIM2
CD4/CD8 ratio
HIV
IL-18
IL-1β
Inflammasome
NAIP
PYCARD
monocytes
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
05 05 2019
05 05 2019
Historique:
received:
31
08
2018
accepted:
21
12
2018
pubmed:
28
12
2018
medline:
17
3
2020
entrez:
28
12
2018
Statut:
ppublish
Résumé
The expression and activity of main inflammasome components in monocytes from successfully treated human immunodeficiency virus (HIV)-positive patients are poorly studied. Thus, we enrolled 18 patients with a low and 17 with a normal ratio of CD4+ T cells to CD8+ T cells and 11 healthy donors. We found that patients with a low ratio had decreased CCR2 expression among classical and intermediate monocytes and increased CCR5 expression among classical monocytes, compared with patients with a normal ratio. Patients with a low ratio also had higher NAIP and PYCARD messenger RNA levels after lipopolysaccharide stimulation, suggesting an altered ability to control immune activation that could affect their immune reconstitution.
Identifiants
pubmed: 30590710
pii: 5257417
doi: 10.1093/infdis/jiy730
doi:
Substances chimiques
CARD Signaling Adaptor Proteins
0
IL18 protein, human
0
IL1B protein, human
0
Inflammasomes
0
Interleukin-18
0
Interleukin-1beta
0
NAIP protein, human
0
Neuronal Apoptosis-Inhibitory Protein
0
PYCARD protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1743-1748Informations de copyright
© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.