L1CAM as a Negative Prognostic Factor in Endometrioid Endometrial Adenocarcinoma FIGO Stage IA-IB.
Adult
Aged
Biomarkers, Tumor
/ genetics
Carcinoma, Endometrioid
/ epidemiology
Cell Adhesion
Disease Progression
Endometrial Neoplasms
/ epidemiology
Female
Gene Expression Regulation, Neoplastic
Humans
Middle Aged
Neoplasm Recurrence, Local
/ epidemiology
Neoplasm Staging
Neural Cell Adhesion Molecule L1
/ genetics
Prognosis
Progression-Free Survival
Endometrial cancer
L1CAM
early stage
recurrence
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
04
11
2018
revised:
19
11
2018
accepted:
21
11
2018
entrez:
29
12
2018
pubmed:
29
12
2018
medline:
8
1
2019
Statut:
ppublish
Résumé
In this study, we aimed to investigate how positivity for L1 cell adhesion molecule (L1CAM) was associated with outcome and relapse pattern in patients with Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) stage IA-IB endometrial cancer. This retrospective study included 358 patients who underwent surgical treatment for endometrial carcinoma. Tumor samples from 312 patients (87.2%) were available for L1CAM analysis by immunohistochemistry. Of the 312 tumor samples analyzed, 93 (29.8%) were L1CAM-positive. L1CAM positivity was significantly more common in grade 3 compared to grade 1-2 carcinomas (p=0.02). Patients with L1CAM positivity more commonly experienced disease progression. Distant metastasis was significantly associated with L1CAM positivity (p=0.01). Progression-free interval and overall survival did not significantly differ between L1CAM-positive and L1CAM-negative cases. L1CAM is a promising independent prognostic marker associated with aggressive tumor behavior and recurrence risk, but not with overall survival.
Identifiants
pubmed: 30591489
pii: 39/1/421
doi: 10.21873/anticanres.13128
doi:
Substances chimiques
Biomarkers, Tumor
0
Neural Cell Adhesion Molecule L1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
421-424Informations de copyright
Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.