Genotoxicity of textile dye C.I. Disperse Blue 291 in mouse bone marrow.
Animals
Azo Compounds
/ pharmacology
Bone Marrow
/ drug effects
Coloring Agents
/ toxicity
Comet Assay
DNA Damage
/ genetics
Erythrocytes, Abnormal
/ drug effects
Gene Expression
/ drug effects
Leukocytes
/ metabolism
Male
Mice
Micronuclei, Chromosome-Defective
/ chemically induced
Proto-Oncogene Proteins c-bcl-2
/ biosynthesis
Smad4 Protein
/ biosynthesis
Tumor Necrosis Factor-alpha
/ biosynthesis
Wastewater
/ chemistry
Azo dye
Comet assay
Micronucleus assay
Journal
Mutation research. Genetic toxicology and environmental mutagenesis
ISSN: 1879-3592
Titre abrégé: Mutat Res Genet Toxicol Environ Mutagen
Pays: Netherlands
ID NLM: 101632149
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
14
08
2018
revised:
11
10
2018
accepted:
11
10
2018
entrez:
1
1
2019
pubmed:
1
1
2019
medline:
14
6
2019
Statut:
ppublish
Résumé
Color Index (C.I.) Disperse Blue 291 (DB291) is an azo dye used by the textile industry. After yarn dyeing, wastewater containing the dye, released into the aquatic environment, may pollute drinking water sources. We investigated the mutagenicity and genotoxicity of DB291 in male Swiss mice, following oral administration. Micronucleated cells, primary DNA damage (comet assay) in blood, liver, and kidney cells, and BAX, BCL2, SMAD4 and TNFA gene expression in leukocytes were evaluated. An increased frequency of micronucleated polychromatic erythrocytes (MNPCEs) was observed in animals treated with 50 mg/kg bw; no other genetic alteration was detected. Neither primary DNA damage nor changes in gene expression were observed.
Identifiants
pubmed: 30595209
pii: S1383-5718(18)30311-5
doi: 10.1016/j.mrgentox.2018.10.003
pii:
doi:
Substances chimiques
Azo Compounds
0
C.I. Disperse Blue 291
0
Coloring Agents
0
Proto-Oncogene Proteins c-bcl-2
0
Smad4 Protein
0
Smad4 protein, mouse
0
Tumor Necrosis Factor-alpha
0
Waste Water
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
48-51Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.