High diversity of Candida glabrata in a tertiary hospital-Mwanza, Tanzania.
C. glabrata
Diversity
MLST
Journal
Medical mycology
ISSN: 1460-2709
Titre abrégé: Med Mycol
Pays: England
ID NLM: 9815835
Informations de publication
Date de publication:
01 Oct 2019
01 Oct 2019
Historique:
received:
21
09
2018
revised:
01
12
2018
accepted:
08
12
2018
pubmed:
1
1
2019
medline:
29
1
2020
entrez:
1
1
2019
Statut:
ppublish
Résumé
Candida glabrata is a genetically diverse human pathogenic yeast, whose subpopulations have been documented to vary geographically. Here, we report MLST genotypes and antifungal drug susceptibility of C. glabrata isolates from Africa. Among 47 mostly urogenital isolates, we found 13 sequence types, amounting to a 27% genetic population difference. More than half of the isolates were of novel sequence types. ST18 was most predominant and had reduced susceptibility to fluconazole. There was clear segregation of STs between urine and vaginal specimen. In Tanzania, the C. glabrata population is genetically diverse, and divergent from those seen in other countries.
Identifiants
pubmed: 30597052
pii: 5266874
doi: 10.1093/mmy/myy151
doi:
Substances chimiques
Antifungal Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
914-917Informations de copyright
© The Author(s) 2018. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology.