Cytogenetic complexity in chronic lymphocytic leukemia: definitions, associations, and clinical impact.
Aged
Biomarkers, Tumor
/ genetics
Chromosome Aberrations
Cytogenetics
/ methods
Female
Follow-Up Studies
Humans
Leukemia, Lymphocytic, Chronic, B-Cell
/ genetics
Male
Middle Aged
Mutation
Prognosis
Retrospective Studies
Somatic Hypermutation, Immunoglobulin
/ genetics
Survival Rate
Tumor Suppressor Protein p53
/ genetics
Journal
Blood
ISSN: 1528-0020
Titre abrégé: Blood
Pays: United States
ID NLM: 7603509
Informations de publication
Date de publication:
14 03 2019
14 03 2019
Historique:
received:
02
09
2018
accepted:
18
12
2018
pubmed:
4
1
2019
medline:
9
11
2019
entrez:
4
1
2019
Statut:
ppublish
Résumé
Recent evidence suggests that complex karyotype (CK) defined by the presence of ≥3 chromosomal aberrations (structural and/or numerical) identified by using chromosome-banding analysis (CBA) may be relevant for treatment decision-making in chronic lymphocytic leukemia (CLL). However, many challenges toward the routine clinical application of CBA remain. In a retrospective study of 5290 patients with available CBA data, we explored both clinicobiological associations and the clinical impact of CK in CLL. We found that patients with ≥5 abnormalities, defined as high-CK, exhibit uniformly dismal clinical outcomes, independently of clinical stage,
Identifiants
pubmed: 30602617
pii: S0006-4971(20)42705-3
doi: 10.1182/blood-2018-09-873083
pmc: PMC6509568
doi:
Substances chimiques
Biomarkers, Tumor
0
TP53 protein, human
0
Tumor Suppressor Protein p53
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1205-1216Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019 by The American Society of Hematology.
Références
Genes Chromosomes Cancer. 2009 Oct;48(10):843-53
pubmed: 19582829
Blood. 2011 Mar 17;117(11):3016-24
pubmed: 21245487
Blood. 2017 Jun 22;129(25):3362-3370
pubmed: 28473407
Genes Chromosomes Cancer. 2016 May;55(5):480-91
pubmed: 26774012
Int J Cancer. 2016 Oct 15;139(8):1759-63
pubmed: 27270786
Blood. 2017 Jun 29;129(26):3495-3498
pubmed: 28446433
Blood. 1980 Oct;56(4):640-7
pubmed: 6968231
Cancer Genet. 2011 Feb;204(2):77-83
pubmed: 21494579
N Engl J Med. 2016 Jan 28;374(4):311-22
pubmed: 26639348
N Engl J Med. 2005 Feb 24;352(8):804-15
pubmed: 15728813
Hematology Am Soc Hematol Educ Program. 2016 Dec 2;2016(1):149-155
pubmed: 27913474
Blood. 1999 Sep 15;94(6):1840-7
pubmed: 10477712
Br J Haematol. 2007 Jul;138(2):217-20
pubmed: 17593029
Leuk Lymphoma. 2013 May;54(5):986-95
pubmed: 22994157
Blood. 2006 Nov 1;108(9):3152-60
pubmed: 16840733
Blood. 2007 Jun 1;109(11):4679-85
pubmed: 17299097
Br J Haematol. 2018 Aug;182(3):412-417
pubmed: 29808933
N Engl J Med. 2000 Dec 28;343(26):1910-6
pubmed: 11136261
Cancer Genet Cytogenet. 2010 Dec;203(2):161-8
pubmed: 21156228
N Engl J Med. 1990 Sep 13;323(11):720-4
pubmed: 2201915
Leukemia. 2014 Mar;28(3):710-3
pubmed: 24217197
Leuk Lymphoma. 2017 Jul;58(7):1548-1560
pubmed: 27808579
Br J Haematol. 2012 Oct;159(1):82-7
pubmed: 22831395
Methods Mol Biol. 2011;730:119-30
pubmed: 21431638
Blood. 2018 Jun 21;131(25):2745-2760
pubmed: 29540348
Haematologica. 2018 Sep;103(9):1511-1517
pubmed: 29880613
Leukemia. 2007 Dec;21(12):2442-51
pubmed: 17805327
Am J Hematol. 2016 Mar;91(3):330-40
pubmed: 26690614
J Intern Med. 2016 Apr;279(4):347-57
pubmed: 26709197
Haematologica. 2014 Jun;99(6):1088-94
pubmed: 24658818
Blood. 2012 May 10;119(19):4467-75
pubmed: 22415752
Haematologica. 2012 Mar;97(3):437-41
pubmed: 22207691
Cancer. 2015 Oct 15;121(20):3612-21
pubmed: 26193999
Br J Haematol. 2018 Apr;181(2):229-233
pubmed: 29611195
Am J Hematol. 2016 Oct;91(10):978-83
pubmed: 27341486
Cancer Genet Cytogenet. 1990 Apr;45(2):143-60
pubmed: 2180558
Blood. 2016 Jul 21;128(3):395-404
pubmed: 27226433
Ann Oncol. 2017 May 1;28(5):1050-1056
pubmed: 28453705
Hematol Oncol. 2017 Dec;35(4):664-670
pubmed: 27678008
Ann Oncol. 2010 Oct;21 Suppl 7:vii154-64
pubmed: 20943609
Nature. 2011 Jun 05;475(7354):101-5
pubmed: 21642962
Blood. 2016 May 19;127(20):2375-90
pubmed: 26980727
Blood. 2016 Apr 7;127(14):1752-60
pubmed: 26841802
Blood. 2016 May 19;127(20):2391-405
pubmed: 27069254
Leukemia. 2013 Feb;27(2):512-4
pubmed: 23138133
Eur J Haematol. 2014 Feb;92(2):91-101
pubmed: 24138550
Haematologica. 2016 Jul;101(7):e299-302
pubmed: 27102498
Oncotarget. 2017 Apr 21;8(33):54297-54303
pubmed: 28903342
Oncotarget. 2016 Dec 6;7(49):80916-80924
pubmed: 27821812
Am J Hematol. 2014 Mar;89(3):249-55
pubmed: 24166834
Blood. 2014 Apr 3;123(14):2139-47
pubmed: 24501221
Blood. 2011 Sep 15;118(11):3051-61
pubmed: 21795749
Haematologica. 2018 Apr;103(4):e158-e161
pubmed: 29269523
Nat Rev Cancer. 2016 Mar;16(3):145-62
pubmed: 26911189
Blood. 2016 Apr 28;127(17):2122-30
pubmed: 26837699
Blood. 2012 Mar 8;119(10):2310-3
pubmed: 22246039
Acta Haematol. 2017;138(1):65-66
pubmed: 28743106
Cancer Genet Cytogenet. 1997 Mar;94(1):27-35
pubmed: 9078288
Blood. 2018 Apr 19;131(16):1820-1832
pubmed: 29358183
Ann Biol Clin (Paris). 2016 Oct 1;74(5):561-567
pubmed: 27628190
Genes Chromosomes Cancer. 2010 Sep;49(9):851-9
pubmed: 20552631
Leukemia. 2012 Jan;26(1):170-2
pubmed: 21788947
Leukemia. 2018 May;32(5):1070-1080
pubmed: 29467486
Blood. 2015 Aug 20;126(8):1043-4
pubmed: 26294719
Haematologica. 2019 Feb;104(2):360-369
pubmed: 30262567
Nature. 2015 Oct 22;526(7574):519-24
pubmed: 26200345
Lancet Oncol. 2016 Jun;17(6):779-790
pubmed: 27185642
Blood. 2000 Dec 15;96(13):4075-83
pubmed: 11110676
Biomed Res Int. 2014;2014:435983
pubmed: 24967369
Haematologica. 2007 Sep;92(9):1242-5
pubmed: 17666364
Leukemia. 2010 Jan;24(1):211-5
pubmed: 19741724
Lancet Haematol. 2014 Nov;1(2):e74-84
pubmed: 27030157
Cancer Genet. 2017 Jan;210:1-8
pubmed: 28212806
Blood. 1999 Sep 15;94(6):1848-54
pubmed: 10477713