Identification of recurrent noncoding mutations in B-cell lymphoma using capture Hi-C.
Computational Biology
/ methods
DNA Copy Number Variations
Databases, Genetic
Gene Amplification
Gene Expression Regulation, Neoplastic
Genetic Association Studies
/ methods
Genetic Predisposition to Disease
Humans
Lymphoma, B-Cell
/ genetics
Mutation
Open Reading Frames
Promoter Regions, Genetic
RNA, Untranslated
/ genetics
Whole Genome Sequencing
Journal
Blood advances
ISSN: 2473-9537
Titre abrégé: Blood Adv
Pays: United States
ID NLM: 101698425
Informations de publication
Date de publication:
08 01 2019
08 01 2019
Historique:
received:
21
09
2018
accepted:
24
11
2018
entrez:
5
1
2019
pubmed:
5
1
2019
medline:
10
1
2020
Statut:
ppublish
Résumé
The identification of driver mutations is fundamental to understanding oncogenesis. Although genes frequently mutated in B-cell lymphoma have been identified, the search for driver mutations has largely focused on the coding genome. Here we report an analysis of the noncoding genome using whole-genome sequencing data from 117 patients with B-cell lymphoma. Using promoter capture Hi-C data in naive B cells, we define
Identifiants
pubmed: 30606723
pii: bloodadvances.2018026419
doi: 10.1182/bloodadvances.2018026419
pmc: PMC6325301
doi:
Substances chimiques
RNA, Untranslated
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
21-32Subventions
Organisme : Cancer Research UK
Pays : United Kingdom
Informations de copyright
© 2019 by The American Society of Hematology.
Références
Nat Genet. 2014 Feb;46(2):116-25
pubmed: 24413735
Bioinformatics. 2018 Oct 1;34(19):3380-3381
pubmed: 29771315
Leuk Res. 2009 Sep;33(9):1276-81
pubmed: 19027161
Curr Protoc Bioinformatics. 2016 Dec 8;56:15.9.1-15.9.17
pubmed: 27930809
Nat Genet. 2014 Nov;46(11):1160-5
pubmed: 25261935
N Engl J Med. 2008 Nov 27;359(22):2313-23
pubmed: 19038878
Br J Cancer. 2015 Apr 28;112(9):1575-84
pubmed: 25867256
Clin Cancer Res. 2017 Apr 1;23(7):1820-1828
pubmed: 27649554
Cell. 2017 Oct 5;171(2):481-494.e15
pubmed: 28985567
Genes Dev. 1989 Jul;3(7):1053-61
pubmed: 2777075
Leukemia. 2018 Nov;32(11):2459-2470
pubmed: 29654271
Nat Genet. 2012 Dec;44(12):1316-20
pubmed: 23143595
Cancer Sci. 2006 Oct;97(10):1050-5
pubmed: 16918993
Nat Commun. 2017 Nov 3;8(1):1315
pubmed: 29101368
Genome Biol. 2016 Jun 15;17(1):127
pubmed: 27306882
EMBO J. 2011 Jun 1;30(11):2281-93
pubmed: 21572390
Bioinformatics. 2016 Oct 1;32(19):3012-4
pubmed: 27288499
Tumour Biol. 2017 Jul;39(7):1010428317714196
pubmed: 28670978
Nat Rev Immunol. 2015 Mar;15(3):172-84
pubmed: 25712152
Nature. 2016 May 02;534(7605):47-54
pubmed: 27135926
Nat Commun. 2018 Oct 1;9(1):4001
pubmed: 30275490
Br J Haematol. 2012 Nov;159(4):441-53
pubmed: 22970711
Bioinformatics. 2013 Dec 1;29(23):2964-70
pubmed: 24021380
Cancer Cell. 2013 Dec 9;24(6):777-90
pubmed: 24332044
Cell. 2016 Nov 17;167(5):1369-1384.e19
pubmed: 27863249
J Cancer. 2015 Aug 07;6(10):953-61
pubmed: 26316891
J Invest Dermatol. 2008 Jul;128(7):1676-85
pubmed: 18256694
Nature. 2010 Feb 18;463(7283):893-8
pubmed: 20164919
Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):139-44
pubmed: 19966280
Haematologica. 2012 Feb;97(2):279-87
pubmed: 21993667
Nat Genet. 2017 Jun;49(6):825-833
pubmed: 28481342
Nature. 2011 Mar 10;471(7337):189-95
pubmed: 21390126
Blood. 2014 Oct 16;124(16):2544-53
pubmed: 25171927
Cancer Sci. 2016 Sep;107(9):1270-80
pubmed: 27348272
Eur J Haematol. 1998 Feb;60(2):125-32
pubmed: 9508354
Nat Genet. 2015 Jul;47(7):710-6
pubmed: 26053494
Genome Biol. 2015 Apr 23;16:84
pubmed: 25903198
Genome Res. 2014 Nov;24(11):1854-68
pubmed: 25122612
Immunity. 2007 Mar;26(3):335-44
pubmed: 17363301
Blood. 2011 May 12;117(19):5019-32
pubmed: 21300984
Blood. 2000 Apr 1;95(7):2312-20
pubmed: 10733501
Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1398-403
pubmed: 23292937
BMC Genomics. 2010 Jan 18;11:41
pubmed: 20082691
Nature. 2017 Jul 6;547(7661):55-60
pubmed: 28658208
Nat Commun. 2015 Dec 07;6:8866
pubmed: 26638776
Nature. 2013 Aug 22;500(7463):415-21
pubmed: 23945592
Leukemia. 2014 Jan;28(1):216-20
pubmed: 23881307
Cell. 2017 Jan 26;168(3):460-472.e14
pubmed: 28089356
Nat Genet. 2018 Oct;50(10):1375-1380
pubmed: 30224643
Cancer Sci. 2009 May;100(5):920-6
pubmed: 19445024
J Exp Med. 2018 Mar 5;215(3):761-771
pubmed: 29374026
Nature. 2015 Oct 22;526(7574):519-24
pubmed: 26200345
Nat Genet. 2010 Feb;42(2):181-5
pubmed: 20081860
Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3879-84
pubmed: 22343534
J Pathol. 2014 Nov;234(3):423-30
pubmed: 25141821
J Exp Med. 2003 May 5;197(9):1093-106
pubmed: 12732655
Mol Cell Biol. 1996 Feb;16(2):609-18
pubmed: 8552089
Oncotarget. 2016 Dec 20;7(51):83987-84002
pubmed: 27276707
Leuk Res. 2013 Jul;37(7):802-8
pubmed: 23608880