Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain.
Acetylcholine
/ pharmacology
Adenosine Triphosphate
/ analogs & derivatives
Adrenal Medulla
/ metabolism
Animals
Capsaicin
/ pharmacology
Catecholamines
/ metabolism
Chromaffin Cells
/ cytology
Disease Models, Animal
Evoked Potentials
/ drug effects
Exocytosis
/ drug effects
Ganglia, Spinal
/ pathology
Male
Membrane Potentials
/ drug effects
Neuralgia
/ metabolism
Neurons
/ pathology
Rats
Rats, Sprague-Dawley
Receptors, Purinergic P2X3
/ genetics
Receptors, Purinergic P2X7
/ genetics
TRPV Cation Channels
/ genetics
P2X3 receptors
P2X7 receptors
TRPV1 channels
adrenal medulla
chromaffin cells
neuropathic pain
stress
α9 nicotinic acetylcholine receptors
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
03 Jan 2019
03 Jan 2019
Historique:
received:
13
12
2018
revised:
25
12
2018
accepted:
26
12
2018
entrez:
6
1
2019
pubmed:
6
1
2019
medline:
12
4
2019
Statut:
epublish
Résumé
We have tested the hypothesis that neuropathic pain acting as a stressor drives functional plasticity in the sympathoadrenal system. The relation between neuropathic pain and adrenal medulla function was studied with behavioral, immunohistochemical and electrophysiological techniques in rats subjected to chronic constriction injury of the sciatic nerve. In slices of the adrenal gland from neuropathic animals, we have evidenced increased cholinergic innervation and spontaneous synaptic activity at the splanchnic nerve⁻chromaffin cell junction. Likewise, adrenomedullary chromaffin cells displayed enlarged acetylcholine-evoked currents with greater sensitivity to α-conotoxin RgIA, a selective blocker of α9 subunit-containing nicotinic acetylcholine receptors, as well as increased exocytosis triggered by voltage-activated Ca
Identifiants
pubmed: 30609840
pii: ijms20010155
doi: 10.3390/ijms20010155
pmc: PMC6337219
pii:
doi:
Substances chimiques
Catecholamines
0
Receptors, Purinergic P2X3
0
Receptors, Purinergic P2X7
0
TRPV Cation Channels
0
Trpv1 protein, rat
0
Adenosine Triphosphate
8L70Q75FXE
Acetylcholine
N9YNS0M02X
alpha,beta-methyleneadenosine 5'-triphosphate
NYX13NT29D
Capsaicin
S07O44R1ZM
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : P01 GM048677
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM103801
Pays : United States
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