Control Mechanism for cis Double-Bond Formation by Polyunsaturated Fatty-Acid Synthases.
biosynthesis
double bonds
enzymes
fatty acids
polyketides
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
18 02 2019
18 02 2019
Historique:
received:
02
11
2018
revised:
30
11
2018
pubmed:
10
1
2019
medline:
15
8
2020
entrez:
10
1
2019
Statut:
ppublish
Résumé
Polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and arachidonic acid (ARA) are essential fatty acids for humans. Some microorganisms biosynthesize these PUFAs through PUFA synthases composed of four subunits with multiple catalytic domains. These PUFA synthases each create a specific PUFA without undesirable byproducts, even though the multiple catalytic domains in each large subunit are very similar. However, the detailed biosynthetic pathways and mechanisms for controlling final-product profiles are still obscure. In this study, the FabA-type dehydratase domain (DH
Identifiants
pubmed: 30623559
doi: 10.1002/anie.201812623
doi:
Substances chimiques
Fatty Acids, Unsaturated
0
Fatty Acid Synthases
EC 2.3.1.85
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2326-2330Subventions
Organisme : Japan Society for the Promotion of Science
ID : 16H06452
Pays : International
Organisme : Japan Society for the Promotion of Science
ID : 15H03110 and 18H03937
Pays : International
Informations de copyright
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.