Novel markers of graft outcome in a cohort of kidney transplanted patients: a cohort observational study.
Adult
Biomarkers
/ metabolism
Biopsy
Cell Adhesion Molecules
/ metabolism
Epithelial-Mesenchymal Transition
Female
Fibrosis
Graft Survival
Humans
Immunohistochemistry
Kidney
/ metabolism
Kidney Diseases
/ etiology
Kidney Transplantation
/ adverse effects
Leukocyte Common Antigens
/ metabolism
Male
Middle Aged
Time Factors
Treatment Outcome
Vimentin
/ metabolism
Fibrosis
Graft outcome
Inflammation
Markers
Renal transplantation
Journal
Journal of nephrology
ISSN: 1724-6059
Titre abrégé: J Nephrol
Pays: Italy
ID NLM: 9012268
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
01
10
2018
accepted:
27
12
2018
pubmed:
11
1
2019
medline:
6
5
2020
entrez:
11
1
2019
Statut:
ppublish
Résumé
Renal biopsy (RBx) informs about kidney transplantation (KTx) prognosis. In our observational study the prevalence of histological anomalies and the prognostic role of CD45, vimentin (VIM) and periostin (POSTN) in KTx-RBx have been evaluated. One hundred forty-six KTx-RBx (2009-2012) were analysed for general histology and in immunohistochemistry for CD45, VIM and POSTN. Clinical data of the 146-KTx patients were collected at the RBx time (T0), 6 and 12 months before and after RBx. Follow-up time was 21 ± 14 months. Glomerulosclerosis was 20% glomeruli/biopsy. Tubular atrophy (TA), Interstitial infiltrate (I-Inf) and interstitial fibrosis (IF) were slight in 21-18% and 25%, moderate in 22-30% and 26% and severe in 30-18% and 28% of patients. Fifty-eight percent of patients had lesions compatible with IF-TA. CD45, VIM and POSTN correlated to each-other and to TA, I-Inf and IF. VIM and POSTN correlated to GS. CD45 and VIM correlated directly to renal function (RF) and 25(OH)VitD, while POSTN inversely to 25(OH)VitD. Thirty patients restarted dialysis (HD+). HD+ had lower T0-eGFR, and higher CD45, VIM and POSTN than HD-. POSTN resulted the strongest in discriminate for HD+ . CD45, VIM and POSTN correlate to each-other and predict graft outcome. POSTN was the strongest in discriminate for HD+. 25(OH)VitD might influence inflammation and fibrosis in KTx.
Identifiants
pubmed: 30628019
doi: 10.1007/s40620-018-00580-0
pii: 10.1007/s40620-018-00580-0
doi:
Substances chimiques
Biomarkers
0
Cell Adhesion Molecules
0
POSTN protein, human
0
VIM protein, human
0
Vimentin
0
Leukocyte Common Antigens
EC 3.1.3.48
PTPRC protein, human
EC 3.1.3.48
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
139-150Références
Mengel M et al (2007) Infiltrates in protocol biopsies from renal allografts. Am J Transplant 7:356–365
doi: 10.1111/j.1600-6143.2006.01635.x
pubmed: 17283485
Zeisberg M, Kalluri R (2004) The role of epithelial-to-mesenchymal transition in renal fibrosis. J Mol Med 82:175–181
doi: 10.1007/s00109-003-0517-9
pubmed: 14752606
Moreso F et al (2007) Immunephenotype of glomerular and interstitial infiltrating cells in protocol renal allograft biopsies and histological diagnosis. Am J Transplant 7:2739–2747
doi: 10.1111/j.1600-6143.2007.02013.x
pubmed: 17949456
Hansson J et al (2014) Evidence for a morphologically distinct and functionally robust cell type in the proximal tubules of human kidney. Hum Pathol 45(2):382–393
doi: 10.1016/j.humpath.2013.10.003
pubmed: 24439225
Rastaldi MP et al (2002) Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies. Kidney Int 62:137–146
doi: 10.1046/j.1523-1755.2002.00430.x
pubmed: 12081572
Doliana R, Bot S, Bonaldo P, Colombatti A (2000) EMI, a novel cysteine-rich domain of EMILINs and other extracellular proteins, interacts with the gC1q domains and participates in multimerization. FEBS Lett 484:164–168
doi: 10.1016/S0014-5793(00)02140-2
pubmed: 11068053
Sorocos K et al (2011) Expression patterns and roles of periostin during kidney and ureter development. J Urol 186:1537–1544
doi: 10.1016/j.juro.2011.05.042
pubmed: 21855915
Wallace DP et al (2013) Periostin promotes renal cyst growth and interstitial fibrosis in polycystic kidney disease. Kidney Int 85:845–854
doi: 10.1038/ki.2013.488
pubmed: 24284511
pmcid: 3972302
Levey AS et al (1999) A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 130:461–470
doi: 10.7326/0003-4819-130-6-199903160-00002
pubmed: 10075613
Walker PD, Cavallo T, Bonsib SM (2004) Ad hoc committee on renal biopsy guidelines of the renal pathology society: Practice guidelines for the renal biopsy. Mod Pathol 17:1555–1563
doi: 10.1038/modpathol.3800239
pubmed: 15272280
Sis B et al (2010) Banff ‘09 meeting report: antibody mediated graft deterioration and implementation of Banff working groups. Am J Transplant 10:464–471
doi: 10.1111/j.1600-6143.2009.02987.x
pubmed: 20121738
Solez K et al (2007) Banff 05 meeting report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy (CAN). Am J Transplant 7:518–526
doi: 10.1111/j.1600-6143.2006.01688.x
pubmed: 17352710
U S Renal Data System (2011) Annual data report: atlas of chronic kidney disease and end-stage renal disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda
Alarrayed S et al (2011) Why does kidney allograft fail? A long-term single-center experience. Saudi J Kidney Dis Transpl. 22:818–824
pubmed: 21743242
Hariharan S, Johnson CP, Bresnahan BA, Taranto SE, McIntosh MJ (2000) Improved graft survival and renal transplantation in the United States, 1988 to 1996. N Engl J Med 342:605–612
doi: 10.1056/NEJM200003023420901
pubmed: 10699159
El-Zoghby ZM et al (2009) Identifying specific causes of kidney allograft loss. Am J Transplant 9:527–535
doi: 10.1111/j.1600-6143.2008.02519.x
pubmed: 19191769
Cosio FG, Gloor JM, Sethi S, Stegall MD (2008) Transplant glomerulopathy. Am J Transplant 8:492–496
doi: 10.1111/j.1600-6143.2007.02104.x
pubmed: 18294145
Naesens M, Kuypers DR, De Vusser K, Evenepoel P, Claes K, Bammens B, Meijers B, Sprangers B, Pirenne J, Monbaliu D, Jochmans I, Lerut E (2014) The histology of kidney transplant failure: a long-term follow-up study. Transplantation 98(4):427–435
doi: 10.1097/TP.0000000000000183
pubmed: 25243513
Gago M, Cornell LD, Kremers WK, Stegall MD, Cosio FG (2012) Kidney allograft inflammation and fibrosis, causes and consequences. Am J Transplant 12:1199–1207
doi: 10.1111/j.1600-6143.2011.03911.x
pubmed: 22221836
Nankivell BJ et al (2001) Effect of histological damage on long-term kidney transplant outcome. Transplantation 71:515–523
doi: 10.1097/00007890-200102270-00006
pubmed: 11258430
Serón D (2009) Interstitial fibrosis and tubular atrophy in renal allograft protocol biopsies as a surrogate of graft survival. Transpl Proc 41:769–770
doi: 10.1016/j.transproceed.2008.12.027
Roufosse C, Simmonds N, Clahsen-van Groningen M, Haas M, Henriksen KJ, Horsfield C, Loupy A, Mengel M, Perkowska-Ptasińska A, Rabant M, Racusen LC, Solez K, Becker JU (2018) A 2018 reference guide to the banff classification of renal allograft pathology. Transplantation 102:1795–1814
doi: 10.1097/TP.0000000000002366
pubmed: 30028786
Doorenbos CRC, van den Born J, Navis G, de Borst MH (2009) Possible renoprotection by vitamin D in chronic renal disease: beyond mineral metabolism. Nat Rev Nephrol 5:691–700
doi: 10.1038/nrneph.2009.185
pubmed: 19859070
Li YC (2010) Renoprotective effects of vitamin D analogs. Kidney Int 78:134–139
doi: 10.1038/ki.2009.175
pubmed: 19471320
Li YC (2012) Vitamin D: roles in renal and cardiovascular protection. Curr Opin Nephrol Hypertens 21:72–79
doi: 10.1097/MNH.0b013e32834de4ee
pubmed: 22143249
pmcid: 3574163
Barros X, Rodríguez NY, Fuster D, Rodas L, Esforzado N, Mazza A, Rubello D, Campos F, Tapias A, Torregrosa JV (2016) Comparison of two different vitamin D supplementation regimens with oral calcifediol in kidney transplant patients. J Nephrol 29:703–709
doi: 10.1007/s40620-015-0237-6
pubmed: 26454858
Messa P, Regalia A, Alfieri CM (2017) Nutritional vitamin D in renal transplant patients: speculations and reality. Nutrients 9(6):550
doi: 10.3390/nu9060550
pmcid: 5490529
Gago M, Cornell LD, Kremers WK, Stegall MD, Cosio FG (2012) Kidney allograft inflammation and fibrosis, causes and consequences. Am J Transplant 12:1199–1207
doi: 10.1111/j.1600-6143.2011.03911.x
pubmed: 22221836
Wei Y, Shao R (2006) Transduction of a mesenchyme-specific gene periostin into 293T cells induces cell invasive activity through epithelial-mesenchymal transformation. J Biol Chem 281(28):19700–19708
doi: 10.1074/jbc.M601856200
Alfieri C et al (2015) Discoidin domain receptor-1 and periostin: new players in chronic kidney disease. Nephrol Dial Transplant 30:1965–1971
doi: 10.1093/ndt/gfv074
pubmed: 25829327
pmcid: 4832988
Oka T et al (2007) Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circ Res 101:313–321
doi: 10.1161/CIRCRESAHA.107.149047
pubmed: 17569887
pmcid: 2680305
Sen K et al (2011) Periostin is induced in glomerular injury and expressed de novo in interstitial renal fibrosis. Am J Pathol 179:1756–1767
doi: 10.1016/j.ajpath.2011.06.002
pubmed: 21854746
pmcid: 3181392
Satirapoj B et al (2014) Urine periostin as a biomarker of renal injury in chronic allograft nephropathy. Transplant Proc 46:135–140
doi: 10.1016/j.transproceed.2013.07.069
pubmed: 24507039
Corren J et al (2011) Lebrikizumab treatment in adults with asthma. N Engl J Med 365:1088–1098
doi: 10.1056/NEJMoa1106469
pubmed: 21812663
Masuoka M et al (2012) Periostin promotes chronic allergic inflammation in response to Th2 cytokines. J Clin Investig 122:2590–2600
doi: 10.1172/JCI58978
pubmed: 22684102
Guerrot D et al (2012) Identification of periostin as a critical marker of progression/reversal of hypertensive nephropathy. PLoS One 7:e31974
doi: 10.1371/journal.pone.0031974
pubmed: 22403621
pmcid: 3293874