Histamine-mediated potentiation of transient receptor potential (TRP) ankyrin 1 and TRP vanilloid 4 signaling in submucosal neurons in patients with irritable bowel syndrome.
TRP channels
histamine 1 receptor
sensitization
visceral hypersensitivity
Journal
American journal of physiology. Gastrointestinal and liver physiology
ISSN: 1522-1547
Titre abrégé: Am J Physiol Gastrointest Liver Physiol
Pays: United States
ID NLM: 100901227
Informations de publication
Date de publication:
01 03 2019
01 03 2019
Historique:
pubmed:
11
1
2019
medline:
27
12
2019
entrez:
11
1
2019
Statut:
ppublish
Résumé
Previously, we showed histamine-mediated sensitization of transient receptor potential (TRP) vanilloid 1 (TRPV1) in patients with irritable bowel syndrome (IBS). Sensitization of TRP ankyrin 1 (TRPA1) and TRP vanilloid 4 (TRPV4) are also involved in aberrant pain perception in preclinical models of somatic pain. Here, we hypothesize that in parallel with TRPV1, histamine sensitizes TRPA1 and TRPV4, contributing to increased visceral pain in patients with IBS. Rectal biopsies were collected from patients with IBS and healthy subjects (HS) to study neuronal sensitivity to TRPA1 and TRPV4 agonists (cinnamaldehyde and GSK1016790A) using intracellular Ca
Identifiants
pubmed: 30629470
doi: 10.1152/ajpgi.00116.2018
doi:
Substances chimiques
TRPV Cation Channels
0
TRPV1 protein, human
0
TRPV1 protein, mouse
0
TRPV1 receptor
0
TRPV4 protein, human
0
Transient Receptor Potential Channels
0
Trpv4 protein, mouse
0
Histamine
820484N8I3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM