Shifts in the selectivity filter dynamics cause modal gating in K


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
10 01 2019
Historique:
received: 01 10 2018
accepted: 07 12 2018
entrez: 12 1 2019
pubmed: 12 1 2019
medline: 21 3 2019
Statut: epublish

Résumé

Spontaneous activity shifts at constant experimental conditions represent a widespread regulatory mechanism in ion channels. The molecular origins of these modal gating shifts are poorly understood. In the K

Identifiants

pubmed: 30631074
doi: 10.1038/s41467-018-07973-6
pii: 10.1038/s41467-018-07973-6
pmc: PMC6328603
doi:

Substances chimiques

Bacterial Proteins 0
Potassium Channels 0
Potassium RWP5GA015D

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

123

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM062342
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM087519
Pays : United States

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Auteurs

Shehrazade Jekhmane (S)

NMR Spectroscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584, CH Utrecht, The Netherlands.

João Medeiros-Silva (J)

NMR Spectroscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584, CH Utrecht, The Netherlands.

Jing Li (J)

Department of Biochemistry and Molecular Biology, The University of Chicago, 929 E57th Street, Chicago, IL, 60637, USA.

Felix Kümmerer (F)

NMR Spectroscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584, CH Utrecht, The Netherlands.

Christoph Müller-Hermes (C)

NMR Spectroscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584, CH Utrecht, The Netherlands.

Marc Baldus (M)

NMR Spectroscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584, CH Utrecht, The Netherlands.

Benoît Roux (B)

Department of Biochemistry and Molecular Biology, The University of Chicago, 929 E57th Street, Chicago, IL, 60637, USA.

Markus Weingarth (M)

NMR Spectroscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584, CH Utrecht, The Netherlands. m.h.weingarth@uu.nl.

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Classifications MeSH