IL-33 Augments Virus-Specific Memory T Cell Inflation and Potentiates the Efficacy of an Attenuated Cytomegalovirus-Based Vaccine.
Adjuvants, Immunologic
/ administration & dosage
Animals
Antibodies, Viral
/ immunology
CD4-Positive T-Lymphocytes
/ drug effects
CD8-Positive T-Lymphocytes
/ drug effects
Cytomegalovirus
Cytomegalovirus Vaccines
/ immunology
Immunologic Memory
Interleukin-33
/ administration & dosage
Mice
Mice, Inbred C57BL
Mice, Knockout
Muromegalovirus
Vaccines, Attenuated
/ immunology
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 02 2019
01 02 2019
Historique:
received:
20
12
2017
accepted:
21
11
2018
pubmed:
13
1
2019
medline:
23
10
2019
entrez:
13
1
2019
Statut:
ppublish
Résumé
Candidate vaccines designed to generate T cell-based immunity are typically vectored by nonpersistent viruses, which largely fail to elicit durable effector memory T cell responses. This limitation can be overcome using recombinant strains of CMV. Proof-of-principle studies have demonstrated the potential benefits of this approach, most notably in the SIV model, but safety concerns require the development of nonreplicating alternatives with comparable immunogenicity. In this study, we show that IL-33 promotes the accumulation and recall kinetics of circulating and tissue-resident memory T cells in mice infected with murine CMV. Using a replication-deficient murine CMV vector, we further show that exogenous IL-33 boosts vaccine-induced memory T cell responses, which protect against subsequent heterologous viral challenge. These data suggest that IL-33 could serve as a useful adjuvant to improve the efficacy of vaccines based on attenuated derivatives of CMV.
Identifiants
pubmed: 30635396
pii: jimmunol.1701757
doi: 10.4049/jimmunol.1701757
pmc: PMC6341181
doi:
Substances chimiques
Adjuvants, Immunologic
0
Antibodies, Viral
0
Cytomegalovirus Vaccines
0
Interleukin-33
0
Vaccines, Attenuated
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
943-955Subventions
Organisme : Medical Research Council
ID : MR/L008734/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 100326
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 098026
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 207503
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 207503/Z/17/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S00971X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_14108
Pays : United Kingdom
Informations de copyright
Copyright © 2019 The Authors.
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