Abundant glutamic acid decarboxylase (GAD)-reactive B cells in gad-antibody-associated neurological disorders.
Adolescent
Adult
Aged
Autoantibodies
/ immunology
B-Lymphocytes
/ immunology
Bone Marrow Cells
/ immunology
Case-Control Studies
Cerebellar Ataxia
/ immunology
Female
Glutamate Decarboxylase
/ immunology
Humans
Immunoglobulin G
/ immunology
Leukocytes, Mononuclear
/ immunology
Limbic Encephalitis
/ immunology
Male
Middle Aged
Plasma Cells
/ immunology
Stiff-Person Syndrome
/ immunology
Young Adult
Journal
Annals of neurology
ISSN: 1531-8249
Titre abrégé: Ann Neurol
Pays: United States
ID NLM: 7707449
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
18
07
2018
revised:
09
01
2019
accepted:
09
01
2019
pubmed:
13
1
2019
medline:
14
1
2020
entrez:
13
1
2019
Statut:
ppublish
Résumé
High levels of antibodies against glutamic acid decarboxylase (GAD) are observed in patients with different neurological disorders, but cells producing these autoantibodies are largely unexplored. We detect circulating GAD-reactive B cells in peripheral blood that readily differentiate into antibody-producing cells. These cells are highly elevated in most patients with GAD-antibody-associated disorders (n = 15) compared to controls (n = 19). They mainly produce GAD65 antibodies of the IgG1 and IgG4 subclasses and are as abundant as B cells reactive for common recall antigens. Bone marrow cells represent an additional source of GAD antibodies. The identification of GAD-antibody-producing cells has implications for the selection of cell-specific biologics. ANN NEUROL 2019;85:448-454.
Substances chimiques
Autoantibodies
0
Immunoglobulin G
0
Glutamate Decarboxylase
EC 4.1.1.15
glutamate decarboxylase 1
EC 4.1.1.15
glutamate decarboxylase 2
EC 4.1.1.15
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
448-454Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB TR128
Pays : International
Organisme : Kompetenznetz Degenerative Demenzen
Pays : International
Organisme : Krankheitsbezogenes Kompetenznetz Multiple Sklerose
Pays : International
Organisme : Federal Ministry of Education and Research
Pays : International
Organisme : Munich Cluster for Systems Neurology
ID : ExC 1010 SyNergy
Pays : International
Informations de copyright
© 2019 American Neurological Association.