Herpes Simplex Virus, APOEɛ4, and Cognitive Decline in Old Age: Results from the Betula Cohort Study.
Adult
Aged
Aged, 80 and over
Antibodies, Viral
/ analysis
Apolipoproteins E
/ genetics
Carrier State
Cognitive Dysfunction
/ epidemiology
Cohort Studies
Cross-Sectional Studies
Female
Follow-Up Studies
Herpes Simplex
/ epidemiology
Heterozygote
Humans
Longitudinal Studies
Male
Memory Disorders
/ epidemiology
Middle Aged
Neuropsychological Tests
Prospective Studies
Simplexvirus
Sweden
/ epidemiology
APOEɛ4
Alzheimer’s disease
apolipoprotein E4
cognitive impairment
cohort study
dementia
epidemiological study
episodic memory
herpes simplex virus
Journal
Journal of Alzheimer's disease : JAD
ISSN: 1875-8908
Titre abrégé: J Alzheimers Dis
Pays: Netherlands
ID NLM: 9814863
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
15
1
2019
pubmed:
15
1
2019
medline:
3
3
2020
Statut:
ppublish
Résumé
Herpes simplex virus (HSV) has been suggested to play a role in Alzheimer's disease (AD) development. The aim of the present study was to investigate the early AD-related symptom episodic memory decline in relation to HSV and carriage of allele 4 of the apolipoprotein E gene (APOEɛ4) in a large population-based cohort with a long follow-up time. The study included 3,413 persons, with longitudinal data available for 1,293 persons with a mean follow-up time of 11.6 years. The associations between HSV carriage, APOEɛ4 carriage, and episodic memory was investigated at baseline, as well as in longitudinal analyses where individuals with and without HSV antibodies (HSV1/2 non-specific) were matched and episodic memory decline compared. Cross-sectional analyses revealed an age-dependent association of HSV carriage with lower episodic memory function, particularly among APOEɛ4 carriers (p = 0.008). Longitudinal analyses showed an increased risk of episodic memory decline in HSV carriers (≥65 years: p < 0.001, all ages: non-significant), and a significant interaction between HSV and APOEɛ4 for episodic memory decline (p < 0.001). In this large population-based cohort study, both cross-sectional and longitudinal results support an association between HSV carriage and declining episodic memory function, especially among APOEɛ4 carriers. The results strengthen the hypothesis that HSV is associated with AD development.
Sections du résumé
BACKGROUND
Herpes simplex virus (HSV) has been suggested to play a role in Alzheimer's disease (AD) development.
OBJECTIVE
The aim of the present study was to investigate the early AD-related symptom episodic memory decline in relation to HSV and carriage of allele 4 of the apolipoprotein E gene (APOEɛ4) in a large population-based cohort with a long follow-up time.
METHODS
The study included 3,413 persons, with longitudinal data available for 1,293 persons with a mean follow-up time of 11.6 years. The associations between HSV carriage, APOEɛ4 carriage, and episodic memory was investigated at baseline, as well as in longitudinal analyses where individuals with and without HSV antibodies (HSV1/2 non-specific) were matched and episodic memory decline compared.
RESULTS
Cross-sectional analyses revealed an age-dependent association of HSV carriage with lower episodic memory function, particularly among APOEɛ4 carriers (p = 0.008). Longitudinal analyses showed an increased risk of episodic memory decline in HSV carriers (≥65 years: p < 0.001, all ages: non-significant), and a significant interaction between HSV and APOEɛ4 for episodic memory decline (p < 0.001).
CONCLUSION
In this large population-based cohort study, both cross-sectional and longitudinal results support an association between HSV carriage and declining episodic memory function, especially among APOEɛ4 carriers. The results strengthen the hypothesis that HSV is associated with AD development.
Identifiants
pubmed: 30636735
pii: JAD171162
doi: 10.3233/JAD-171162
doi:
Substances chimiques
Antibodies, Viral
0
Apolipoproteins E
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM