Anti-mitochondria antibody-related tubulointerstitial nephritis accompanied by severe hypokalemic paralysis.
Autoimmune Diseases
/ complications
Biopsy
Glucocorticoids
/ administration & dosage
Humans
Hypokalemia
/ drug therapy
Kidney
/ pathology
Male
Middle Aged
Mitochondria
/ immunology
Nephritis, Interstitial
/ complications
Paralysis
Prednisolone
/ administration & dosage
Respiratory Insufficiency
/ diagnosis
Treatment Outcome
Hypokalemia
Respiratory failure
Tubulitis
Journal
CEN case reports
ISSN: 2192-4449
Titre abrégé: CEN Case Rep
Pays: Japan
ID NLM: 101636244
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
22
08
2018
accepted:
06
01
2019
pubmed:
15
1
2019
medline:
19
3
2020
entrez:
15
1
2019
Statut:
ppublish
Résumé
A 47-year-old man presented with severe hypokalemic paralysis and respiratory failure. A large amount of potassium was administered along with providing intensive care, and his condition improved. Hypokalemia was attributed to increased urinary potassium excretion. A kidney biopsy was performed to make a definitive histological diagnosis. It revealed acute tubulointerstitial nephritis (TIN). After the diagnosis, prednisolone was administered, and the TIN gradually improved. From the clinical course and laboratory findings, the TIN was presumed to be an autoimmune disorder. Further specific autoantibody tests were positive for anti-mitochondrial antibody (AMA), which has been gaining increasing attention in regard to TIN. In addition, all previous cases of TIN associated with AMA have affected females. The detailed pathogenetic mechanisms are as yet unclear and require further investigation.
Identifiants
pubmed: 30637665
doi: 10.1007/s13730-019-00376-6
pii: 10.1007/s13730-019-00376-6
pmc: PMC6450987
doi:
Substances chimiques
Glucocorticoids
0
Prednisolone
9PHQ9Y1OLM
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
119-124Références
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