Synthesis and evaluation of novel substituted 1,2,3-triazolyldihydroquinolines as promising antitubercular agents.

Antitubercular Agents / chemical synthesis Microbial Sensitivity Tests Mycobacterium tuberculosis / drug effects Quinolines / chemical synthesis Triazoles / chemistry
Dihydroquinoline Mycobacterium tuberculosis Thiophene Triazole

Journal

Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377

Informations de publication

Date de publication:
15 02 2019
Historique:
received: 01 09 2018
revised: 28 12 2018
accepted: 05 01 2019
pubmed: 15 1 2019
medline: 7 3 2020
entrez: 15 1 2019
Statut: ppublish

Résumé

A series of novel substituted 1,2,3-triazolyldihydroquinolines 6a-o was designed and synthesized from 2-acetylthiophene in five-step reaction sequence involving modified Boltzmann-Rahtz reaction of β-Enaminone; Vilsmeier-Haack chloroformylation using DMF/POCl

Identifiants

DOI: 10.1016/j.bmcl.2019.01.004 PMID: 30638877
pubmed: 30638877
pii: S0960-894X(19)30004-6
doi: 10.1016/j.bmcl.2019.01.004
pii:
doi:

Substances chimiques

Antitubercular Agents 0
Quinolines 0
Triazoles 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

529-533

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Sandeep Kumar Marvadi (SK)

Fluoro & Agrochemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, Telangana, India.

Vagolu Siva Krishna (VS)

Medicinal Chemistry and Antimycobacterial Research Laboratory, Pharmacy Group, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Jawahar Nagar, Hyderabad 500078, Telangana, India.

Dharmarajan Sriram (D)

Medicinal Chemistry and Antimycobacterial Research Laboratory, Pharmacy Group, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Jawahar Nagar, Hyderabad 500078, Telangana, India.

Srinivas Kantevari (S)

Fluoro & Agrochemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, Telangana, India; Academy of Scientific and Innovative Research, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, Telangana, India. Electronic address: ksrinivas@iict.res.in.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Antituberculeux › Synthesis and evaluation of novel substituted...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Synthesis and evaluation of novel substituted...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › Synthesis and evaluation of novel substituted...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Synthesis and evaluation of novel substituted...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Triazoles › Synthesis and evaluation of novel substituted...