Prevalence of Salmonella Typhi, its associated factors and antimicrobial susceptibility profile among patients attending Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia.
Humans
Ethiopia
/ epidemiology
Salmonella typhi
/ drug effects
Male
Cross-Sectional Studies
Adult
Female
Prevalence
Typhoid Fever
/ epidemiology
Young Adult
Adolescent
Anti-Bacterial Agents
/ pharmacology
Middle Aged
Microbial Sensitivity Tests
Child
Child, Preschool
Hospitals, University
Feces
/ microbiology
Hospitals, Special
/ statistics & numerical data
Salmonella
Ethiopia
Hawassa
Stool culture
Typhoid fever
Journal
BMC infectious diseases
ISSN: 1471-2334
Titre abrégé: BMC Infect Dis
Pays: England
ID NLM: 100968551
Informations de publication
Date de publication:
31 Oct 2024
31 Oct 2024
Historique:
received:
02
07
2024
accepted:
24
10
2024
medline:
1
11
2024
pubmed:
1
11
2024
entrez:
1
11
2024
Statut:
epublish
Résumé
Salmonella Typhi infections cause significant morbidity and mortality worldwide, especially in developing countries including Ethiopia. This study aimed to determine the prevalence of Salmonella Typhi, its associated factors and antibiotic susceptibility profile among suspected typhoid patients. A cross-sectional study was conducted on 270 typhoid fever suspected patients at Hawassa University Comprehensive Specialized Hospital from June 2022 to September 2022. Data were collected using questionnaires by face-to-face interview. Stool samples for microbiological culture, blood samples for S. Typhi IgM/Entero-check WB rapid test and isolates for antimicrobial susceptibility tests were used through standard procedures and according to the reagents manufactures' instructions. Hygiene implementation of patients was also assessed using interview. Sociodemographic and clinical characteristics of the patient's were considered. Descriptive statistics were used to summarize the data, and logistic regression model analysis was performed to assess associations between S. Typhi infection and the associated sociodemographic and clinical factors. The prevalence of S. Typhi IgM/Entero-check WB rapid test and stool culture results were 3.3%; (95% CI: 1.5-5.6) and 3.7%; (95% CI: 1.9-6.3) respectively. Not washing hands after latrine [AOR = 0.85, 95% CI (0.15-4.79), p = 0.05] is not significant but, not washing hands before meal [AOR = 0.053, 95% CI (0.08-0.36), p = 0.03], eating raw vegetables [AOR = 0.024, 95% CI (0.001-0.48), p = 0.015] and drinking water from a stream [AOR = 0.12, 95% CI (0.19-0.70), p = 0.001] were significantly associated with S. Typhi infection, but in terms of AOR, all are preventive. Susceptibility of isolates was 9/10 (90%), 8/10 (80%), and 8/10 (80%) to ciprofloxacin, ceftriaxone, and chloramphenicol, respectively. The majorities 100% and 80% of the isolates were resistant to ampicillin and cotrimoxazole, respectively. About 40% of the isolates were MDR. The prevalence of Salmonella Typhi with MDR has been observed. Therefore, health programmers and stakeholders should make efforts to improve the habit of sanitation, strengthen the capacity of laboratory diagnostic methods and increase awareness of the misprescription and misuse of antibiotics to reduce the impact of MDR bacteria.
Identifiants
pubmed: 39482629
doi: 10.1186/s12879-024-10118-4
pii: 10.1186/s12879-024-10118-4
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1224Informations de copyright
© 2024. The Author(s).
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