Autonomic functions and gastric motility in children with functional abdominal pain disorders.
Abdominal pain
Autonomic function
Functional gastrointestinal disorders
Gastric motility
Journal
World journal of gastroenterology
ISSN: 2219-2840
Titre abrégé: World J Gastroenterol
Pays: United States
ID NLM: 100883448
Informations de publication
Date de publication:
07 Jan 2019
07 Jan 2019
Historique:
received:
12
09
2018
revised:
01
12
2018
accepted:
13
12
2018
entrez:
16
1
2019
pubmed:
16
1
2019
medline:
29
1
2019
Statut:
ppublish
Résumé
Abdominal pain-predominant functional gastrointestinal disorders (AP-FGIDs) are the most common cause of recurrent abdominal pain in children. Despite its high prevalence, the underlying pathophysiology of this condition is poorly understood. To assess the role of gastric dysmotility and autonomic nervous system dysfunction in the pathophysiology of AP-FGIDs. One hundred children, fulfilling Rome III criteria for AP-FGIDs, and 50 healthy controls, aged 5 to 12 years, were recruited after obtaining parental consent. All patients were investigated for underlying organic disorders. Gastric motility and cardiovascular autonomic functions were assessed using validated non-invasive techniques. The main gastric motility parameters assessed (gastric emptying rate [45.7 Children with AP-FGIDs have abnormal gastric motility but normal cardiovascular autonomic functions. There is no relationship between abnormal gastric motility and autonomic functions. The pathogenesis of AP-FGIDs is not related to cardiovascular autonomic dysfunction.
Sections du résumé
BACKGROUND
BACKGROUND
Abdominal pain-predominant functional gastrointestinal disorders (AP-FGIDs) are the most common cause of recurrent abdominal pain in children. Despite its high prevalence, the underlying pathophysiology of this condition is poorly understood.
AIM
OBJECTIVE
To assess the role of gastric dysmotility and autonomic nervous system dysfunction in the pathophysiology of AP-FGIDs.
METHODS
METHODS
One hundred children, fulfilling Rome III criteria for AP-FGIDs, and 50 healthy controls, aged 5 to 12 years, were recruited after obtaining parental consent. All patients were investigated for underlying organic disorders. Gastric motility and cardiovascular autonomic functions were assessed using validated non-invasive techniques.
RESULTS
RESULTS
The main gastric motility parameters assessed (gastric emptying rate [45.7
CONCLUSION
CONCLUSIONS
Children with AP-FGIDs have abnormal gastric motility but normal cardiovascular autonomic functions. There is no relationship between abnormal gastric motility and autonomic functions. The pathogenesis of AP-FGIDs is not related to cardiovascular autonomic dysfunction.
Identifiants
pubmed: 30643361
doi: 10.3748/wjg.v25.i1.95
pmc: PMC6328964
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
95-106Déclaration de conflit d'intérêts
Conflict-of-interest statement: No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.
Références
Neurology. 1999 Feb;52(3):523-8
pubmed: 10025781
J Pediatr Gastroenterol Nutr. 2000 Feb;30(2):157-63
pubmed: 10697134
J Gastroenterol Hepatol. 2000 Sep;15(9):1022-7
pubmed: 11059931
Am J Gastroenterol. 2001 Feb;96(2):460-6
pubmed: 11232691
Biol Res Nurs. 2000 Oct;2(2):97-106
pubmed: 11337820
Dig Dis Sci. 2001 Jun;46(6):1276-84
pubmed: 11414305
Acta Paediatr. 2001 Jun;90(6):632-7
pubmed: 11440095
J Pediatr Gastroenterol Nutr. 2001 Jul;33(1):47-53
pubmed: 11479407
Eur J Ultrasound. 2001 Jul;13(3):205-13
pubmed: 11516632
Gut. 2002 Jul;51 Suppl 1:i25-8
pubmed: 12077060
Cephalalgia. 2003;23 Suppl 1:43-8
pubmed: 12699458
Headache. 1992 Feb;32(2):105-7
pubmed: 1551788
Gastroenterology. 2006 Apr;130(5):1527-37
pubmed: 16678566
Clin Neurophysiol. 2006 Jul;117(7):1545-50
pubmed: 16737848
Arthritis Res Ther. 2007;9(4):216
pubmed: 17626613
J Clin Biochem Nutr. 2008 Mar;42(2):144-9
pubmed: 18385832
J Gastroenterol Hepatol. 2008 Nov;23(11):1672-7
pubmed: 18752559
Biol Psychol. 2009 Oct;82(2):101-10
pubmed: 19463887
J Gastroenterol Hepatol. 2009 Aug;24(8):1347-51
pubmed: 19702902
Int J Cardiol. 2010 May 28;141(2):122-31
pubmed: 19910061
J Pediatr Gastroenterol Nutr. 2011 Dec;53(6):659-65
pubmed: 21697745
Neurogastroenterol Motil. 2012 Feb;24(2):108-12, e81
pubmed: 22103293
Neurogastroenterol Motil. 2012 May;24(5):420-5, e207
pubmed: 22273006
J Pain. 2012 May;13(5):477-84
pubmed: 22520688
J Pediatr Gastroenterol Nutr. 2013 Apr;56(4):443-8
pubmed: 23201712
J Gastroenterol Hepatol. 2013 Jul;28(7):1161-6
pubmed: 23517336
Neurogastroenterol Motil. 2013 Oct;25(10):e650-9
pubmed: 23822743
J Dig Dis. 2013 Dec;14(12):638-46
pubmed: 23927739
Bull Exp Biol Med. 2013 Oct;155(6):705-7
pubmed: 24288745
BMC Gastroenterol. 2014 Aug 21;14:150
pubmed: 25145589
Nat Rev Gastroenterol Hepatol. 2015 Mar;12(3):159-71
pubmed: 25666642
Neurogastroenterol Motil. 2015 May;27(5):684-92
pubmed: 25809794
PLoS One. 2015 May 20;10(5):e0126982
pubmed: 25992621
BMC Gastroenterol. 2016 Feb 29;16:26
pubmed: 26924750
Diabetes Care. 1985 Sep-Oct;8(5):491-8
pubmed: 4053936
N Y State J Med. 1982 May;82(6):903-8
pubmed: 7048158
Clin Sci (Lond). 1982 Jan;62(1):57-64
pubmed: 7056031
Pain. 1982 Jul;13(3):287-98
pubmed: 7122114
Dig Dis Sci. 1995 Jul;40(7):1428-34
pubmed: 7628264
Gastroenterology. 1994 Apr;106(4):945-50
pubmed: 8143999
Gut. 1994 Mar;35(3):327-32
pubmed: 8150341
Scand J Gastroenterol. 1993 Jan;28(1):63-8
pubmed: 8381557
Scand J Gastroenterol. 1993 Apr;28(4):355-60
pubmed: 8488369
Gastroenterology. 1996 Apr;110(4):1036-42
pubmed: 8612991
Dig Dis Sci. 1996 Apr;41(4):689-96
pubmed: 8674389
J Paediatr Child Health. 1995 Dec;31(6):545-8
pubmed: 8924309
Ann N Y Acad Sci. 1998 May 1;840:33-44
pubmed: 9629234
Gastroenterology. 1998 Dec;115(6):1346-52
pubmed: 9834261