Plantaricins markedly enhance the effects of traditional antibiotics against Staphylococcus epidermidis.
Amino Acid Sequence
Anti-Bacterial Agents
/ pharmacology
Bacteriocins
/ chemistry
Cell Membrane
/ drug effects
Colony Count, Microbial
Drug Combinations
Drug Synergism
Liposomes
Microbial Sensitivity Tests
Microbial Viability
/ drug effects
Protein Precursors
/ pharmacology
Staphylococcal Infections
/ drug therapy
Staphylococcus epidermidis
/ cytology
None
Pln
antibiotic
combination therapy
liposome
membrane lysis
plantaricin
synergy
Journal
Future microbiology
ISSN: 1746-0921
Titre abrégé: Future Microbiol
Pays: England
ID NLM: 101278120
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
pubmed:
17
1
2019
medline:
14
5
2019
entrez:
17
1
2019
Statut:
ppublish
Résumé
Bacteriocins are considered as promising alternatives to antibiotics against infections. In this study, the plantaricins (Pln) A, E, F, J and K were investigated for their antimicrobial activity against Staphylococcus epidermidis. The effects on membrane integrity were studied using liposomes and viable bacteria, respectively. We show that PlnEF and PlnJK caused rapid and significant lysis of S. epidermidis, and induced lysis of liposomes. The PlnEF and PlnJK displayed similar mechanisms by targeting and disrupting the bacterial cell membrane. Interestingly, Pln enhanced the effects of different antibiotics by 30- to 500-fold. This study shows that Pln in combination with low concentrations of antibiotics is efficient against S. epidermidis and may be developed as potential treatment of infections.
Identifiants
pubmed: 30648887
doi: 10.2217/fmb-2018-0285
pmc: PMC6393846
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacteriocins
0
Drug Combinations
0
Liposomes
0
Protein Precursors
0
plantaricin EF
0
plantaricin JK
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
195-205Références
Biochemistry. 2016 Sep 13;55(36):5106-16
pubmed: 27538436
Microbiologyopen. 2016 Aug;5(4):700-8
pubmed: 27150273
Crit Care Med. 2007 Aug;35(8):1888-95
pubmed: 17581492
Trends Biotechnol. 2013 Mar;31(3):177-84
pubmed: 23333434
J Bacteriol. 1999 Aug;181(16):4848-52
pubmed: 10438754
Nature. 2011 Aug 24;476(7361):393-4
pubmed: 21866137
J Infect Chemother. 2015 Nov;21(11):808-15
pubmed: 26423688
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2017 Dec;34(12):2058-2068
pubmed: 28795907
J Bacteriol. 1999 Feb;181(3):740-7
pubmed: 9922235
Clin Microbiol Rev. 2012 Jul;25(3):450-70
pubmed: 22763634
Front Microbiol. 2014 May 26;5:241
pubmed: 24904554
Nat Rev Microbiol. 2013 Feb;11(2):95-105
pubmed: 23268227
Fungal Biol. 2014 Feb;118(2):264-75
pubmed: 24528647
Pathog Dis. 2017 Jul 31;75(5):
pubmed: 28605543
Chemotherapy. 1998 Mar-Apr;44(2):94-8
pubmed: 9551238
Proc Natl Acad Sci U S A. 2007 May 1;104(18):7617-21
pubmed: 17456596
Ups J Med Sci. 2014 May;119(2):149-53
pubmed: 24666223
Curr Microbiol. 2018 Mar;75(3):272-277
pubmed: 29058043
Nurse Educ Pract. 2016 Jan;16(1):188-92
pubmed: 26213148
Clin Infect Dis. 2003 Feb 15;36(4):429-39
pubmed: 12567300
BMC Microbiol. 2016 Aug 18;16(1):188
pubmed: 27538539
Drug Resist Updat. 2017 Mar;31:1-14
pubmed: 28867240
J Am Geriatr Soc. 2018 Aug;66(8):1581-1586
pubmed: 30094828
Nat Rev Microbiol. 2009 Aug;7(8):555-67
pubmed: 19609257
J Biol Chem. 2005 Jun 17;280(24):22945-50
pubmed: 15805109
Infect Dis Clin North Am. 2009 Mar;23(1):73-98
pubmed: 19135917
Lancet Infect Dis. 2016 Feb;16(2):239-51
pubmed: 26795692
Zhonghua Fu Chan Ke Za Zhi. 1996 Aug;31(8):477-9
pubmed: 9275440
Peptides. 2009 Aug;30(8):1562-74
pubmed: 19465075
Pharmacogn Rev. 2015 Jan-Jun;9(17):29-34
pubmed: 26009690
Front Microbiol. 2016 Apr 18;7:508
pubmed: 27148197
Ann Clin Microbiol Antimicrob. 2017 Sep 19;16(1):63
pubmed: 28927452
J Antimicrob Chemother. 2010 Jan;65(1):24-36
pubmed: 19861337
Cell Mol Life Sci. 2016 Dec;73(23):4471-4492
pubmed: 27392605
Appl Environ Microbiol. 1998 Jun;64(6):2269-72
pubmed: 9603847
Poult Sci. 2003 Apr;82(4):640-7
pubmed: 12710486
J Cosmet Laser Ther. 2016 Aug;18(4):188-92
pubmed: 26735085