A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs.
ATR/ATM
BRC-1
DNA damage response
DNA double-strand breaks
inter-sister repair
meiosis
synaptonemal complex
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
15 01 2019
15 01 2019
Historique:
received:
11
05
2018
revised:
28
09
2018
accepted:
17
12
2018
entrez:
17
1
2019
pubmed:
17
1
2019
medline:
10
4
2020
Statut:
ppublish
Résumé
Accurate meiotic chromosome segregation critically depends on the formation of inter-homolog crossovers initiated by double-strand breaks (DSBs). Inaccuracies in this process can drive aneuploidy and developmental defects, but how meiotic cells are protected from unscheduled DNA breaks remains unexplored. Here we define a checkpoint response to persistent meiotic DSBs in C. elegans that phosphorylates the synaptonemal complex (SC) to switch repair partner from the homolog to the sister chromatid. A key target of this response is the core SC component SYP-1, which is phosphorylated in response to ionizing radiation (IR) or unrepaired meiotic DSBs. Failure to phosphorylate (syp-1
Identifiants
pubmed: 30650366
pii: S2211-1247(18)32019-9
doi: 10.1016/j.celrep.2018.12.074
pmc: PMC6334227
pii:
doi:
Substances chimiques
DNA-Binding Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
775-787.e5Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Cancer Research UK
ID : FC0010048
Pays : United Kingdom
Organisme : Medical Research Council
ID : FC0010048
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC0010048
Pays : United Kingdom
Informations de copyright
Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.
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