The Clonal Evolution of Metastatic Osteosarcoma as Shaped by Cisplatin Treatment.

Antineoplastic Agents / pharmacology Bone Neoplasms / drug therapy Cisplatin / pharmacology Clonal Evolution / drug effects DNA Mutational Analysis Female Humans Lung Neoplasms / drug therapy Male Models, Genetic Mutagenesis / drug effects Neoplasm Metastasis Osteosarcoma / drug therapy Whole Genome Sequencing

Journal

Molecular cancer research : MCR
ISSN: 1557-3125
Titre abrégé: Mol Cancer Res
Pays: United States
ID NLM: 101150042

Informations de publication

Date de publication:
04 2019
Historique:
received: 11 06 2018
revised: 17 10 2018
accepted: 07 01 2019
pubmed: 18 1 2019
medline: 10 1 2020
entrez: 18 1 2019
Statut: ppublish

Résumé

To investigate the genomic evolution of metastatic pediatric osteosarcoma, we performed whole-genome and targeted deep sequencing on 14 osteosarcoma metastases and two primary tumors from four patients (two to eight samples per patient). All four patients harbored ancestral (truncal) somatic variants resulting in

Identifiants

DOI: 10.1158/1541-7786.MCR-18-0620 PMID: 30651371 PMC: PMC8518028
pubmed: 30651371
pii: 1541-7786.MCR-18-0620
doi: 10.1158/1541-7786.MCR-18-0620
pmc: PMC8518028
mid: NIHMS1518716
doi:

Substances chimiques

Antineoplastic Agents 0
Cisplatin Q20Q21Q62J

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

895-906

Subventions

Organisme : NCI NIH HHS
ID : P30 CA021765
Pays : United States

Informations de copyright

©2019 American Association for Cancer Research.

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Auteurs

Samuel W Brady (SW)

Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Xiaotu Ma (X)

Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Armita Bahrami (A)

Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Gryte Satas (G)

Department of Computer Science, Princeton University, Princeton, New Jersey.

Gang Wu (G)

Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Scott Newman (S)

Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Michael Rusch (M)

Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
ORCID: 0000-0002-5363-1848

Daniel K Putnam (DK)

Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
ORCID: 0000-0001-8080-775X

Heather L Mulder (HL)

Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Donald A Yergeau (DA)

UB Genomics and Bioinformatics Core, University at Buffalo, Buffalo, New York.

Michael N Edmonson (MN)

Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
ORCID: 0000-0003-0339-700X

John Easton (J)

Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Ludmil B Alexandrov (LB)

Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California.

Xiang Chen (X)

Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Elaine R Mardis (ER)

Institute for Genomic Medicine, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, Ohio.

Richard K Wilson (RK)

Institute for Genomic Medicine, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, Ohio.

James R Downing (JR)

Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Alberto S Pappo (AS)

Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Benjamin J Raphael (BJ)

Department of Computer Science, Princeton University, Princeton, New Jersey.
ORCID: 0000-0003-1274-048X

Michael A Dyer (MA)

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee. Jinghui.Zhang@StJude.org Mike.Dyer@StJude.org.

Jinghui Zhang (J)

Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee. Jinghui.Zhang@StJude.org Mike.Dyer@StJude.org.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › The Clonal Evolution of Metastatic...
questionsmedicales.fr › Maladies ostéomusculaires › Maladies osseuses › Tumeurs osseuses › The Clonal Evolution of Metastatic...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du platine › Cisplatine › The Clonal Evolution of Metastatic...
questionsmedicales.fr › Phénomènes génétiques › Évolution clonale › The Clonal Evolution of Metastatic...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Analyse de mutations d'ADN › The Clonal Evolution of Metastatic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Clonal Evolution of Metastatic...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › The Clonal Evolution of Metastatic...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles génétiques › The Clonal Evolution of Metastatic...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › The Clonal Evolution of Metastatic...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Métastase tumorale › The Clonal Evolution of Metastatic...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu conjonctif et des tissus mous › Sarcomes › Ostéosarcome › The Clonal Evolution of Metastatic...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Séquençage du génome entier › The Clonal Evolution of Metastatic...