HIF-1α metabolically controls collagen synthesis and modification in chondrocytes.

Animals Bone Diseases / metabolism Cartilage / metabolism Chondrocytes / metabolism Collagen / biosynthesis Extracellular Matrix / metabolism Glucose / metabolism Glutamine / metabolism Growth Plate / metabolism Hydroxylation Hypoxia-Inducible Factor 1, alpha Subunit / metabolism Hypoxia-Inducible Factor-Proline Dioxygenases / deficiency Ketoglutaric Acids / metabolism Lysine / metabolism Male Mice Osteogenesis Oxidation-Reduction Proline / metabolism

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
01 2019
Historique:
received: 01 11 2017
accepted: 05 12 2018
pubmed: 18 1 2019
medline: 14 6 2019
entrez: 18 1 2019
Statut: ppublish

Résumé

Endochondral ossification, an important process in vertebrate bone formation, is highly dependent on correct functioning of growth plate chondrocytes

Identifiants

DOI: 10.1038/s41586-019-0874-3 PMID: 30651640 PMC: PMC7195049
pubmed: 30651640
doi: 10.1038/s41586-019-0874-3
pii: 10.1038/s41586-019-0874-3
pmc: PMC7195049
mid: NIHMS1576233
doi:

Substances chimiques

Hif1a protein, mouse 0
Hypoxia-Inducible Factor 1, alpha Subunit 0
Ketoglutaric Acids 0
Glutamine 0RH81L854J
Collagen 9007-34-5
Proline 9DLQ4CIU6V
Egln1 protein, mouse EC 1.14.11.29
Hypoxia-Inducible Factor-Proline Dioxygenases EC 1.14.11.29
Glucose IY9XDZ35W2
Lysine K3Z4F929H6

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

511-515

Subventions

Organisme : NICHD NIH HHS
ID : P01 HD070394
Pays : United States
Organisme : NIAMS NIH HHS
ID : R37 AR037318
Pays : United States
Organisme : NIH HHS
ID : AR037318
Pays : United States
Organisme : NIH HHS
ID : HD070394
Pays : United States

Références

Biochem J. 1995 Nov 15;312 ( Pt 1):163-7
pubmed: 7492307
Stem Cells. 2014 Sep;32(9):2407-18
pubmed: 24989687
J Clin Invest. 2004 Jan;113(2):188-99
pubmed: 14722611
Curr Opin Biotechnol. 2015 Aug;34:189-201
pubmed: 25731751
J Bone Miner Res. 1993 Sep;8(9):1031-43
pubmed: 8237472
Cell Metab. 2016 Feb 9;23(2):265-79
pubmed: 26863487
Nat Rev Dis Primers. 2017 Aug 18;3:17052
pubmed: 28820180
Nat Rev Cancer. 2016 Sep 23;16(10):663-73
pubmed: 27658636
Cytometry A. 2006 Jan;69(1):1-12
pubmed: 16342116
Biol Cell. 2015 Aug;107(8):251-72
pubmed: 25913226
Nat Commun. 2017 May 11;8:15267
pubmed: 28492237
Circulation. 2010 Jul 20;122(3):273-81
pubmed: 20606119
Cell Metab. 2008 Sep;8(3):257-65
pubmed: 18762026
J Bone Miner Res. 2013 Jan;28(1):2-17
pubmed: 23197339
Biochim Biophys Acta. 1995 Aug 17;1245(1):43-8
pubmed: 7544626
Bone. 2011 Oct;49(4):613-22
pubmed: 21763477
Cell Rep. 2016 Oct 11;17(3):837-848
pubmed: 27732858
Biotechniques. 1997 Apr;22(4):656-8
pubmed: 9105617
J Biol Chem. 2012 Oct 26;287(44):37134-44
pubmed: 22930750
Biochem J. 1979 Sep 1;181(3):639-45
pubmed: 42386
Nature. 2003 May 15;423(6937):332-6
pubmed: 12748651
Genesis. 2000 Feb;26(2):145-6
pubmed: 10686612
Nat Rev Mol Cell Biol. 2014 Dec;15(12):786-801
pubmed: 25415508
Cell Metab. 2009 Jan 7;9(1):11-22
pubmed: 19117543
J Biol Chem. 1985 Mar 25;260(6):3440-50
pubmed: 3838314
Genes Dev. 2001 Nov 1;15(21):2865-76
pubmed: 11691837
Cold Spring Harb Protoc. 2014 Mar 01;2014(3):263-70
pubmed: 24591684
J Clin Invest. 2010 Jun;120(6):2171-83
pubmed: 20440072
J Endocrinol. 1989 Jan;120(1):143-51
pubmed: 2783957
J Bone Miner Res. 2012 Mar;27(3):596-609
pubmed: 22162090
Ann Med. 2008;40(6):402-17
pubmed: 19160570
Am J Physiol Cell Physiol. 2011 Mar;300(3):C385-93
pubmed: 21123733
J Bone Miner Res. 2010 Jul;25(7):1468-86
pubmed: 20533309
J Bone Miner Res. 2000 Aug;15(8):1510-6
pubmed: 10934649
Cell Calcium. 2010 Aug-Sep;48(2-3):161-7
pubmed: 20801505
J Biol Chem. 2010 Jan 22;285(4):2580-90
pubmed: 19940144
Metab Eng. 2017 Sep;43(Pt B):187-197
pubmed: 27847310
Trends Mol Med. 2012 Sep;18(9):534-43
pubmed: 22921864
Nat Commun. 2018 Jul 2;9(1):2557
pubmed: 29967369
J Cell Sci. 1994 Dec;107 ( Pt 12):3379-92
pubmed: 7535784
Trends Genet. 2004 Jan;20(1):33-43
pubmed: 14698617
Nat Rev Cancer. 2016 Oct;16(10):619-34
pubmed: 27492215
Bone. 2016 Jun;87:176-86
pubmed: 27058876
Cell. 2009 Mar 6;136(5):839-851
pubmed: 19217150
J Mater Sci Mater Med. 2004 Aug;15(8):925-32
pubmed: 15477745
J Cell Sci. 2003 May 1;116(Pt 9):1819-26
pubmed: 12665562
Nat Med. 2012 Jul 06;18(7):1028-40
pubmed: 22772564
Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9493-8
pubmed: 8790358
FASEB J. 2009 Jan;23(1):232-40
pubmed: 18809737

Auteurs

Steve Stegen (S)

Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.

Kjell Laperre (K)

Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.

Guy Eelen (G)

Laboratory of Angiogenesis and Vascular Biology, VIB Center for Cancer Biology, VIB, Leuven, Belgium.
Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, Leuven, Belgium.

Gianmarco Rinaldi (G)

Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.
Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, Leuven, Belgium.

Peter Fraisl (P)

Laboratory of Angiogenesis and Vascular Biology, VIB Center for Cancer Biology, VIB, Leuven, Belgium.
Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, Leuven, Belgium.

Sophie Torrekens (S)

Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.

Riet Van Looveren (R)

Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.

Shauni Loopmans (S)

Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.

Geert Bultynck (G)

Laboratory of Molecular and Cellular Signalling, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.

Stefan Vinckier (S)

Laboratory of Angiogenesis and Vascular Biology, VIB Center for Cancer Biology, VIB, Leuven, Belgium.
Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, Leuven, Belgium.

Filip Meersman (F)

Molecular and Nanomaterials, KU Leuven, Leuven, Belgium.

Patrick H Maxwell (PH)

Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.

Jyoti Rai (J)

Department of Orthopaedics, University of Washington, Seattle, WA, USA.

MaryAnn Weis (M)

Department of Orthopaedics, University of Washington, Seattle, WA, USA.

David R Eyre (DR)

Department of Orthopaedics, University of Washington, Seattle, WA, USA.

Bart Ghesquière (B)

Metabolomics Expertise Center, Department of Oncology, KU Leuven/VIB Center for Cancer Biology Leuven, Leuven, Belgium.

Sarah-Maria Fendt (SM)

Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.
Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, Leuven, Belgium.

Peter Carmeliet (P)

Laboratory of Angiogenesis and Vascular Biology, VIB Center for Cancer Biology, VIB, Leuven, Belgium.
Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, Leuven, Belgium.
State Key Laboratory of Ophtalmology, Zhongshan Ophtalmic Center, Sun Yat-Sen University, Guangzhou, China.

Geert Carmeliet (G)

Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium. geert.carmeliet@kuleuven.be.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › HIF-1α metabolically controls collagen...
questionsmedicales.fr › Maladies ostéomusculaires › Maladies osseuses › HIF-1α metabolically controls collagen...
questionsmedicales.fr › Tissus › Tissu conjonctif › Cartilage › HIF-1α metabolically controls collagen...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Chondrocytes › HIF-1α metabolically controls collagen...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Collagène › HIF-1α metabolically controls collagen...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Matrice extracellulaire › HIF-1α metabolically controls collagen...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › HIF-1α metabolically controls collagen...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés neutres › Glutamine › HIF-1α metabolically controls collagen...
questionsmedicales.fr › Appareil locomoteur › Squelette › Épiphyses (os) › Lame épiphysaire › HIF-1α metabolically controls collagen...
questionsmedicales.fr › Métabolisme › Hydroxylation › HIF-1α metabolically controls collagen...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › Facteur-1 induit par l'hypoxie › Sous-unité alpha du facteur-1 induit par l'hypoxie › HIF-1α metabolically controls collagen...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Mixed function oxygenases › Prolyl hydroxylases › Hypoxia-inducible factor-proline dioxygenases › HIF-1α metabolically controls collagen...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Cétoacides › Acides cétoglutariques › HIF-1α metabolically controls collagen...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Lysine › HIF-1α metabolically controls collagen...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › HIF-1α metabolically controls collagen...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Développement locomoteur › Biominéralisation › Développement osseux › Ostéogenèse › HIF-1α metabolically controls collagen...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › HIF-1α metabolically controls collagen...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés cycliques › Imino-acides › Proline › HIF-1α metabolically controls collagen...