Expectancy-Related Changes in Dopaminergic Error Signals Are Impaired by Cocaine Self-Administration.
Action Potentials
/ drug effects
Analysis of Variance
Animals
Choice Behavior
Cocaine
/ administration & dosage
Conditioning, Operant
/ drug effects
Cues
Dopamine Uptake Inhibitors
/ administration & dosage
Dopaminergic Neurons
/ drug effects
Rats
Reward
Self Administration
Ventral Tegmental Area
/ cytology
addiction
cocaine
dopamine
learning
prediction error
rodent
single-unit
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
16 01 2019
16 01 2019
Historique:
received:
21
05
2018
revised:
30
08
2018
accepted:
13
11
2018
entrez:
18
1
2019
pubmed:
18
1
2019
medline:
14
8
2019
Statut:
ppublish
Résumé
Addiction is a disorder of behavioral control and learning. While this may reflect pre-existing propensities, drug use also clearly contributes by causing changes in outcome processing in prefrontal and striatal regions. This altered processing is associated with behavioral deficits, including changes in learning. These areas provide critical input to midbrain dopamine neurons regarding expected outcomes, suggesting that effects on learning may result from changes in dopaminergic error signaling. Here, we show that dopamine neurons recorded in rats that had self-administered cocaine failed to suppress firing on omission of an expected reward and exhibited lower amplitude and imprecisely timed increases in firing to an unexpected reward. Learning also appeared to have less of an effect on reward-evoked and cue-evoked firing in the cocaine-experienced rats. Overall, the changes are consistent with reduced fidelity of input regarding the expected outcomes, such as their size, timing, and overall value, because of cocaine use.
Identifiants
pubmed: 30653935
pii: S0896-6273(18)31016-X
doi: 10.1016/j.neuron.2018.11.025
pmc: PMC6338441
mid: NIHMS1512990
pii:
doi:
Substances chimiques
Dopamine Uptake Inhibitors
0
Cocaine
I5Y540LHVR
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Pagination
294-306.e3Subventions
Organisme : Intramural NIH HHS
ID : Z99 DA999999
Pays : United States
Informations de copyright
Published by Elsevier Inc.
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