Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families.

Autoantibodies / immunology Autoimmunity / genetics Diabetes Mellitus, Type 1 / genetics Genetic Predisposition to Disease / genetics Genotype HLA-DQ Antigens / genetics Humans Islets of Langerhans / metabolism Proportional Hazards Models Risk Factors

Journal

Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763

Informations de publication

Date de publication:
04 2019
Historique:
received: 16 08 2018
accepted: 04 01 2019
pubmed: 19 1 2019
medline: 24 9 2019
entrez: 19 1 2019
Statut: ppublish

Résumé

The risk for autoimmunity and subsequently type 1 diabetes is 10-fold higher in children with a first-degree family history of type 1 diabetes (FDR children) than in children in the general population (GP children). We analyzed children with high-risk HLA genotypes (

Identifiants

DOI: 10.2337/db18-0882 PMID: 30655385 PMC: PMC6425872
pubmed: 30655385
pii: db18-0882
doi: 10.2337/db18-0882
pmc: PMC6425872
doi:

Substances chimiques

Autoantibodies 0
HLA-DQ Antigens 0

Banques de données

ClinicalTrials.gov
['NCT00279318']

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

847-857

Subventions

Organisme : NIDDK NIH HHS
ID : U01 DK063821
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK063863
Pays : United States
Organisme : NIDDK NIH HHS
ID : DP3 DK111906
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK063861
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK063790
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001082
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK017047
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000064
Pays : United States
Organisme : NLM NIH HHS
ID : HHSN267200700014C
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK063836
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK063829
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK063865
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK095300
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK063861
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK063829
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK063821
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK117483
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK063836
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK112243
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK063865
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK063863
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK106955
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK100238
Pays : United States

Investigateurs

Marian Rewers (M)
Kimberly Bautista (K)
Judith Baxter (J)
Daniel Felipe-Morales (D)
Kimberly Driscoll (K)
Brigitte I Frohnert (BI)
Marisa Gallant (M)
Patricia Gesualdo (P)
Michelle Hoffman (M)
Rachel Karban (R)
Edwin Liu (E)
Jill Norris (J)
Adela Samper-Imaz (A)
Andrea Steck (A)
Kathleen Waugh (K)
Hali Wright (H)
Jorma Toppari (J)
Olli G Simell (OG)
Annika Adamsson (A)
Suvi Ahonen (S)
Heikki Hyöty (H)
Jorma Ilonen (J)
Mirva Koreasalo (M)
Kalle Kurppa (K)
Tiina Latva-Aho (T)
Maria Lönnrot (M)
Markus Mattila (M)
Elina Mäntymäki (E)
Katja Multasuo (K)
Tina Niininen (T)
Sari Niinistö (S)
Mia Nyblom (M)
Paula Ollikainen (P)
Petra Rajala (P)
Jenna Rautanen (J)
Anne Riikonen (A)
Minna Romo (M)
Suvi Ruohonen (S)
Juulia Rönkä (J)
Sini Vainionpää (S)
Eeva Varjonen (E)
Riitta Veijola (R)
Suvi M Virtanen (SM)
Mari Vähä-Mäkilä (M)
Mari Åkerlund (M)
Katri Lindfors (K)
Jin-Xiong She (JX)
Desmond Schatz (D)
Diane Hopkins (D)
Leigh Steed (L)
Jennifer Bryant (J)
Janey Adams (J)
Katherine Silvis (K)
Michael Haller (M)
Melissa Gardiner (M)
Richard McIndoe (R)
Ashok Sharma (A)
Stephen W Anderson (SW)
Laura Jacobsen (L)
John Marks (J)
P D Towe (PD)
Anette G Ziegler (AG)
Andreas Beyerlein (A)
Ezio Bonifacio (E)
Anita Gavrisan (A)
Cigdem Gezginci (C)
Anja Heublein (A)
Michael Hummel (M)
Sandra Hummel (S)
Annette Knopff (A)
Charlotte Koch (C)
Sibylle Koletzko (S)
Claudia Ramminger (C)
Roswith Roth (R)
Marlon Scholz (M)
Joanna Stock (J)
Katharina Warncke (K)
Lorena Wendel (L)
Christiane Winkler (C)
Åke Lernmark (Å)
Daniel Agardh (D)
Carin Andrén Aronsson (C)
Maria Ask (M)
Jenny Bremer (J)
Ulla-Marie Carlsson (UM)
Corrado Cilio (C)
Emelie Ericson-Hallström (E)
Annika Fors (A)
Lina Fransson (L)
Fredrik Johansen (F)
Berglind Jonsdottir (B)
Silvija Jovic (S)
Helena Elding Larsson (H)
Marielle Lindström (M)
Markus Lundgren (M)
Maria Månsson-Martinez (M)
Maria Markan (M)
Jessica Melin (J)
Zeliha Mestan (Z)
Caroline Nilsson (C)
Karin Ottoson (K)
Kobra Rahmati (K)
Anita Ramelius (A)
Falastin Salami (F)
Sara Sibthorpe (S)
Anette Sjöberg (A)
Birgitta Sjöberg (B)
Carina Törn (C)
Anne Wallin (A)
Åsa Wimar (Å)
Sofie Åberg (S)
William A Hagopian (WA)
Michael Killian (M)
Claire Cowen Crouch (C)
Jennifer Skidmore (J)
Ashley Akramoff (A)
Jana Banjanin (J)
Masumeh Chavoshi (M)
Kayleen Dunson (K)
Rachel Hervey (R)
Rachel Lyons (R)
Arlene Meyer (A)
Denise Mulenga (D)
Jared Radtke (J)
Davey Schmitt (D)
Julie Schwabe (J)
Sarah Zink (S)
Dorothy Becker (D)
Margaret Franciscus (M)
MaryEllen Dalmagro-Elias Smith (M)
Ashi Daftary (A)
Mary Beth Klein (MB)
Chrystal Yates (C)
Jeffrey P Krischer (JP)
Sarah Austin-Gonzalez (S)
Maryouri Avendano (M)
Sandra Baethke (S)
Rasheedah Brown (R)
Brant Burkhardt (B)
Martha Butterworth (M)
Joanna Clasen (J)
David Cuthbertson (D)
Christopher Eberhard (C)
Steven Fiske (S)
Dena Garcia (D)
Jennifer Garmeson (J)
Veena Gowda (V)
Kathleen Heyman (K)
Belinda Hsiao (B)
Francisco Perez Laras (F)
Hye-Seung Lee (HS)
Shu Liu (S)
Xiang Liu (X)
Kristian Lynch (K)
Colleen Maguire (C)
Jamie Malloy (J)
Cristina McCarthy (C)
Aubrie Merrell (A)
Steven Meulemans (S)
Hemang Parikh (H)
Ryan Quigley (R)
Cassandra Remedios (C)
Chris Shaffer (C)
Laura Smith (L)
Susan Smith (S)
Noah Sulman (N)
Roy Tamura (R)
Ulla Uusitalo (U)
Kendra Vehik (K)
Ponni Vijayakandipan (P)
Keith Wood (K)
Jimin Yang (J)
Michael Abbondondolo (M)
Lori Ballard (L)
David Hadley (D)
Wendy McLeod (W)
Beena Akolkar (B)
Kasia Bourcier (K)
Thomas Briese (T)
Suzanne Bennett Johnson (S)
Eric Triplett (E)
Liping Yu (L)
Dongmei Miao (D)
Polly Bingley (P)
Alistair Williams (A)
Kyla Chandler (K)
Olivia Ball (O)
Ilana Kelland (I)
Sian Grace (S)
Ben Gillard (B)
William Hagopian (W)
Masumeh Chavoshi (M)
Jared Radtke (J)
Julie Schwabe (J)
Henry Erlich (H)
Steven J Mack (SJ)
Anna Lisa Fear (AL)
Stephen S Rich (SS)
Wei-Min Chen (WM)
Suna Onengut-Gumuscu (S)
Emily Farber (E)
Rebecca Roche Pickin (R)
Jonathan Davis (J)
Jordan Davis (J)
Dan Gallo (D)
Jessica Bonnie (J)
Paul Campolieto (P)
Sandra Ke (S)
Niveen Mulholland (N)

Informations de copyright

© 2019 by the American Diabetes Association.

Références

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Auteurs

Markus Hippich (M)

Institute of Diabetes Research, Helmholtz Zentrum München (German Research Center for Environmental Health), Munich-Neuherberg, Germany.

Andreas Beyerlein (A)

Institute of Diabetes Research, Helmholtz Zentrum München (German Research Center for Environmental Health), Munich-Neuherberg, Germany.
Forschergruppe Diabetes, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
ORCID: 0000-0001-6603-5036

William A Hagopian (WA)

Pacific Northwest Research Institute, Seattle, WA.

Jeffrey P Krischer (JP)

Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL.

Kendra Vehik (K)

Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL.

Jan Knoop (J)

Institute of Diabetes Research, Helmholtz Zentrum München (German Research Center for Environmental Health), Munich-Neuherberg, Germany.

Christiane Winker (C)

Institute of Diabetes Research, Helmholtz Zentrum München (German Research Center for Environmental Health), Munich-Neuherberg, Germany.
Forschergruppe Diabetes e.V., Helmholtz Zentrum München (German Research Center for Environmental Health), Munich-Neuherberg, Germany.

Jorma Toppari (J)

Department of Pediatrics, Turku University Hospital, and Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland.

Åke Lernmark (Å)

Department of Clinical Sciences, Lund University/CRC, Skåne University Hospital SUS, Malmo, Sweden.

Marian J Rewers (MJ)

Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO.

Andrea K Steck (AK)

Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO.
ORCID: 0000-0002-5931-9484

Jin-Xiong She (JX)

Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA.

Beena Akolkar (B)

National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD.

Catherine C Robertson (CC)

Center for Public Health Genomics, University of Virginia, Charlottesville, VA.

Suna Onengut-Gumuscu (S)

Center for Public Health Genomics, University of Virginia, Charlottesville, VA.
ORCID: 0000-0002-6563-8334

Stephen S Rich (SS)

Center for Public Health Genomics, University of Virginia, Charlottesville, VA.
ORCID: 0000-0003-3872-7793

Ezio Bonifacio (E)

Forschergruppe Diabetes e.V., Helmholtz Zentrum München (German Research Center for Environmental Health), Munich-Neuherberg, Germany anette-g.ziegler@helmholtz-muenchen.de ezio.bonifacio@tu-dresden.de.
DFG Center for Regenerative Therapies Dresden, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.

Anette-G Ziegler (AG)

Institute of Diabetes Research, Helmholtz Zentrum München (German Research Center for Environmental Health), Munich-Neuherberg, Germany anette-g.ziegler@helmholtz-muenchen.de ezio.bonifacio@tu-dresden.de.
Forschergruppe Diabetes, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
Forschergruppe Diabetes e.V., Helmholtz Zentrum München (German Research Center for Environmental Health), Munich-Neuherberg, Germany.
ORCID: 0000-0002-6290-5548

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Autoanticorps › Genetic Contribution to the Divergence in Type...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Auto-immunité › Genetic Contribution to the Divergence in Type...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Diabète de type 1 › Genetic Contribution to the Divergence in Type...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Genetic Contribution to the Divergence in Type...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Genetic Contribution to the Divergence in Type...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes HLA › Antigènes HLA-D › Antigènes HLA-DQ › Genetic Contribution to the Divergence in Type...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genetic Contribution to the Divergence in Type...
questionsmedicales.fr › Système endocrine › Glandes endocrines › Ilots pancréatiques › Genetic Contribution to the Divergence in Type...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Modèles des risques proportionnels › Genetic Contribution to the Divergence in Type...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Genetic Contribution to the Divergence in Type...