Repeated cell transplantation and adjunct renal denervation in ischemic heart failure: exploring modalities for improving cell therapy efficacy.
Cell therapy
Cellular post-conditioning
Fibrosis
Ischemia–reperfusion injury
Left ventricular function
Stem cells
Sympathetic nervous system
Journal
Basic research in cardiology
ISSN: 1435-1803
Titre abrégé: Basic Res Cardiol
Pays: Germany
ID NLM: 0360342
Informations de publication
Date de publication:
17 01 2019
17 01 2019
Historique:
received:
26
11
2018
accepted:
09
01
2019
revised:
20
12
2018
entrez:
19
1
2019
pubmed:
19
1
2019
medline:
14
6
2019
Statut:
epublish
Résumé
Enthusiasm for cell therapy for myocardial injury has waned due to equivocal benefits in clinical trials. In an attempt to improve efficacy, we investigated repeated cell therapy and adjunct renal denervation (RDN) as strategies for augmenting cardioprotection with cardiosphere-derived cells (CDCs). We hypothesized that combining CDC post-conditioning with repeated CDC doses or delayed RDN therapy would result in superior function and remodeling. Wistar-Kyoto (WKY) rats or spontaneously hypertensive rats (SHR) were subjected to 45 min of coronary artery ligation followed by reperfusion for 12-14 weeks. In the first study arm, SHR were treated with CDCs (0.5 × 10
Identifiants
pubmed: 30656501
doi: 10.1007/s00395-019-0718-1
pii: 10.1007/s00395-019-0718-1
pmc: PMC7121860
mid: NIHMS1562380
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL093579
Pays : United States
Organisme : NHLBI NIH HHS
ID : 1R01 HL092141
Pays : United States
Organisme : NHLBI NIH HHS
ID : 1R01 HL093579
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133835
Pays : United States
Organisme : NHLBI NIH HHS
ID : P20 HL113452
Pays : United States
Organisme : NHLBI NIH HHS
ID : 1U24 HL 094373
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL092141
Pays : United States
Organisme : NHLBI NIH HHS
ID : U24 HL094373
Pays : United States
Organisme : NHLBI NIH HHS
ID : 1P20 HL113452
Pays : United States
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