Type 1 Diabetes Risk in African-Ancestry Participants and Utility of an Ancestry-Specific Genetic Risk Score.
Alleles
Black People
/ genetics
Case-Control Studies
Diabetes Mellitus, Type 1
/ ethnology
Female
Genetic Predisposition to Disease
Genetic Testing
/ methods
Genome-Wide Association Study
HLA-D Antigens
/ genetics
HLA-DQ alpha-Chains
/ genetics
HLA-DQ beta-Chains
/ genetics
HLA-DRB1 Chains
/ genetics
Haplotypes
Humans
Male
Polymorphism, Single Nucleotide
Predictive Value of Tests
Research Design
Risk Factors
White People
/ genetics
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
13
08
2018
accepted:
14
12
2018
pubmed:
20
1
2019
medline:
31
10
2019
entrez:
20
1
2019
Statut:
ppublish
Résumé
Genetic risk scores (GRS) have been developed that differentiate individuals with type 1 diabetes from those with other forms of diabetes and are starting to be used for population screening; however, most studies were conducted in European-ancestry populations. This study identifies novel genetic variants associated with type 1 diabetes risk in African-ancestry participants and develops an African-specific GRS. We generated single nucleotide polymorphism (SNP) data with the ImmunoChip on 1,021 African-ancestry participants with type 1 diabetes and 2,928 control participants. HLA class I and class II alleles were imputed using SNP2HLA. Logistic regression models were used to identify genome-wide significant ( African-specific (HLA- Genetic risk of type 1 diabetes includes ancestry-specific, disease-associated variants. The GRS developed here provides improved prediction of type 1 diabetes in African-ancestry subjects and a means to identify groups of individuals who would benefit from immune monitoring for early detection of islet autoimmunity.
Identifiants
pubmed: 30659077
pii: dc18-1727
doi: 10.2337/dc18-1727
pmc: PMC6385701
doi:
Substances chimiques
HLA-D Antigens
0
HLA-DQ alpha-Chains
0
HLA-DQ beta-Chains
0
HLA-DQA1 antigen
0
HLA-DQB1 antigen
0
HLA-DRB1 Chains
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
406-415Subventions
Organisme : NIAID NIH HHS
ID : P01 AI042288
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG008965
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK079626
Pays : United States
Organisme : NLM NIH HHS
ID : T32 LM012416
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002319
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK062431
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK106718
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK017047
Pays : United States
Informations de copyright
© 2019 by the American Diabetes Association.
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