Patients With Idiopathic Scoliosis Run an Increased Risk of Schizophrenia.
Adolescent
Chromosomes, Human, Pair 22
/ genetics
Cohort Studies
Female
Follow-Up Studies
Gene Deletion
Humans
Male
Physical Appearance, Body
Prevalence
Proportional Hazards Models
Retrospective Studies
Schizophrenia
/ epidemiology
Schizophrenic Psychology
Scoliosis
/ complications
Syndrome
Time Factors
Etiology
Genetics
Idiopathic scoliosis
Schizophrenia
Journal
Spine deformity
ISSN: 2212-1358
Titre abrégé: Spine Deform
Pays: England
ID NLM: 101603979
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
30
11
2017
revised:
20
06
2018
accepted:
14
07
2018
entrez:
21
1
2019
pubmed:
21
1
2019
medline:
3
7
2019
Statut:
ppublish
Résumé
Retrospective cohort study. To investigate a possible linkage between idiopathic scoliosis (IS) and schizophrenia in an adolescent population. There is an interesting link between schizophrenia and idiopathic scoliosis: schizophrenia is a disturbance of mental equilibrium, and scoliosis of physical equilibrium, both are multifactorial, genetically determined, start at a young age, and brain development is thought to play a role. Furthermore, both may be presenting symptoms of the genetic disorder 22q11 deletion syndrome. This study poses the question whether these two poorly understood disorders are related. A retrospective cohort study was conducted and consisted of 3,702 Swedish adolescents, collected from the National Patient Register, that underwent inpatient care for IS during 1997-2015. These were matched by age, sex, and date of diagnosis to 370,200 controls, collected from Swedish population data, and then followed up in the National Patient Register to identify in- and outpatient care for schizophrenia diagnosis. Follow-up time was calculated from first IS diagnosis date until date of schizophrenia diagnosis or end of follow-up. Cox proportional regression analysis was performed to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) for being diagnosed with schizophrenia. Over a median follow-up time of 9.5 years, 0.7% of patients with IS developed schizophrenia versus 0.5% of controls (p = .04). The risk of schizophrenia was significantly higher in patients with IS (HR, 1.52; 95% CI, 1.03-2.23). Using only hospitalized schizophrenia as event, the prevalence for schizophrenia was 0.5% versus 0.3% (p ≤.01; HR, 1.83; 95% CI, 1.17-2.84). This study suggests that patients with IS have increased risk of schizophrenia. Dissatisfaction with one's physical appearance might lead to psychological distress and provoke mental illness in predisposed persons. Alternatively, these two disorders may share a common genetic background. Level 2B.
Sections du résumé
STUDY DESIGN
Retrospective cohort study.
OBJECTIVES
To investigate a possible linkage between idiopathic scoliosis (IS) and schizophrenia in an adolescent population.
SUMMARY OF BACKGROUND DATA
There is an interesting link between schizophrenia and idiopathic scoliosis: schizophrenia is a disturbance of mental equilibrium, and scoliosis of physical equilibrium, both are multifactorial, genetically determined, start at a young age, and brain development is thought to play a role. Furthermore, both may be presenting symptoms of the genetic disorder 22q11 deletion syndrome. This study poses the question whether these two poorly understood disorders are related.
METHODS
A retrospective cohort study was conducted and consisted of 3,702 Swedish adolescents, collected from the National Patient Register, that underwent inpatient care for IS during 1997-2015. These were matched by age, sex, and date of diagnosis to 370,200 controls, collected from Swedish population data, and then followed up in the National Patient Register to identify in- and outpatient care for schizophrenia diagnosis. Follow-up time was calculated from first IS diagnosis date until date of schizophrenia diagnosis or end of follow-up. Cox proportional regression analysis was performed to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) for being diagnosed with schizophrenia.
RESULTS
Over a median follow-up time of 9.5 years, 0.7% of patients with IS developed schizophrenia versus 0.5% of controls (p = .04). The risk of schizophrenia was significantly higher in patients with IS (HR, 1.52; 95% CI, 1.03-2.23). Using only hospitalized schizophrenia as event, the prevalence for schizophrenia was 0.5% versus 0.3% (p ≤.01; HR, 1.83; 95% CI, 1.17-2.84).
CONCLUSION
This study suggests that patients with IS have increased risk of schizophrenia. Dissatisfaction with one's physical appearance might lead to psychological distress and provoke mental illness in predisposed persons. Alternatively, these two disorders may share a common genetic background.
LEVEL OF EVIDENCE
Level 2B.
Identifiants
pubmed: 30660220
pii: S2212-134X(18)30139-4
doi: 10.1016/j.jspd.2018.07.003
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
262-266Informations de copyright
Copyright © 2018 Scoliosis Research Society. Published by Elsevier Inc. All rights reserved.