Norepinephrine control of ventromedial hypothalamic nucleus glucoregulatory neurotransmitter expression in the female rat: Role of monocarboxylate transporter function.
Animals
Astrocytes
/ metabolism
Coumaric Acids
/ pharmacology
Enzyme Inhibitors
/ pharmacology
Estrogen Receptor beta
/ metabolism
Estrogens
/ deficiency
Fatty Acids
/ metabolism
Female
Glucose
/ metabolism
Glycogen
/ metabolism
Glycogen Synthase
/ antagonists & inhibitors
Monocarboxylic Acid Transporters
/ antagonists & inhibitors
Norepinephrine
/ metabolism
Rats
Rats, Sprague-Dawley
Receptors, Adrenergic
/ metabolism
Ventromedial Hypothalamic Nucleus
/ cytology
Glutamate decarboxylase
Glycogen phosphorylase
Monocarboxylate transporter
Nitric oxide synthase
Norepinephrine
Ventromedial hypothalamic nucleus
Journal
Molecular and cellular neurosciences
ISSN: 1095-9327
Titre abrégé: Mol Cell Neurosci
Pays: United States
ID NLM: 9100095
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
24
09
2018
revised:
09
01
2019
accepted:
16
01
2019
pubmed:
21
1
2019
medline:
12
4
2019
entrez:
21
1
2019
Statut:
ppublish
Résumé
The ventromedial hypothalamic nucleus (VMN) is a critical component of the neural circuitry that regulates glucostasis. Astrocyte glycogen is a vital reserve of glucose and its oxidizable metabolite L-lactate. In hypoglycemic female rats, estradiol-dependent augmentation of VMN glycogen phosphorylase (GP) protein requires hindbrain catecholamine input. Research here investigated the premise that norepinephrine (NE) regulation of VMN astrocyte metabolism shapes local glucoregulatory neurotransmitter signaling in this sex. Estradiol-implanted ovariectomized rats were pretreated by intra-VMN administration of the monocarboxylate transporter inhibitor alpha-cyano-4-hydroxy-cinnamic acid (4CIN) or vehicle before NE delivery to that site. NE caused 4CIN-reversible reduction or augmentation of VMN glycogen synthase and phosphorylase expression. 4CIN prevented NE stimulation of gluco-inhibitory (glutamate decarboxylase
Identifiants
pubmed: 30660767
pii: S1044-7431(18)30303-8
doi: 10.1016/j.mcn.2019.01.004
pmc: PMC6472905
mid: NIHMS1521629
pii:
doi:
Substances chimiques
Coumaric Acids
0
Enzyme Inhibitors
0
Estrogen Receptor beta
0
Estrogens
0
Fatty Acids
0
Monocarboxylic Acid Transporters
0
Receptors, Adrenergic
0
alpha-cyano-4-hydroxycinnamate
28166-41-8
Glycogen
9005-79-2
Glycogen Synthase
EC 2.4.1.11
Glucose
IY9XDZ35W2
Norepinephrine
X4W3ENH1CV
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
51-58Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK109382
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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