Commonality despite exceptional diversity in the baseline human antibody repertoire.

Antibodies / chemistry Antigens / immunology B-Lymphocytes / cytology Base Sequence Clone Cells / cytology Genetic Variation / genetics Humans Sequence Analysis, DNA

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
02 2019
Historique:
received: 19 09 2017
accepted: 22 11 2018
pubmed: 22 1 2019
medline: 14 8 2019
entrez: 22 1 2019
Statut: ppublish

Résumé

In principle, humans can produce an antibody response to any non-self-antigen molecule in the appropriate context. This flexibility is achieved by the presence of a large repertoire of naive antibodies, the diversity of which is expanded by somatic hypermutation following antigen exposure

Identifiants

DOI: 10.1038/s41586-019-0879-y PMID: 30664748 PMC: PMC6411386
pubmed: 30664748
doi: 10.1038/s41586-019-0879-y
pii: 10.1038/s41586-019-0879-y
pmc: PMC6411386
mid: NIHMS1514269
doi:

Substances chimiques

Antibodies 0
Antigens 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Pagination

393-397

Subventions

Organisme : NIAID NIH HHS
ID : U19 AI135995
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI100663
Pays : United States

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Auteurs

Bryan Briney (B)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. briney@scripps.edu.
Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA, USA. briney@scripps.edu.
Center for Viral Systems Biology, The Scripps Research Institute, La Jolla, CA, USA. briney@scripps.edu.
IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA. briney@scripps.edu.
Human Vaccines Project, New York, NY, USA. briney@scripps.edu.

Anne Inderbitzin (A)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Collin Joyce (C)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA, USA.
Center for Viral Systems Biology, The Scripps Research Institute, La Jolla, CA, USA.
IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.

Dennis R Burton (DR)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. burton@scripps.edu.
Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA, USA. burton@scripps.edu.
IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA. burton@scripps.edu.
Human Vaccines Project, New York, NY, USA. burton@scripps.edu.
Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. burton@scripps.edu.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Commonality despite exceptional diversity in...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Commonality despite exceptional diversity in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Commonality despite exceptional diversity in...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence nucléotidique › Commonality despite exceptional diversity in...
questionsmedicales.fr › Cellules › Cellules cultivées › Clones cellulaires › Commonality despite exceptional diversity in...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Commonality despite exceptional diversity in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Commonality despite exceptional diversity in...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Commonality despite exceptional diversity in...