Small-molecule targeting of brachyury transcription factor addiction in chordoma.
Cell Proliferation
/ drug effects
Chordoma
/ genetics
Cyclin-Dependent Kinases
/ metabolism
Down-Regulation
/ drug effects
Fetal Proteins
/ metabolism
Genes, Essential
Humans
Protein Kinase Inhibitors
/ pharmacology
Small Molecule Libraries
/ pharmacology
T-Box Domain Proteins
/ metabolism
Transcription Factors
/ metabolism
Journal
Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
22
01
2018
accepted:
26
11
2018
pubmed:
22
1
2019
medline:
11
5
2019
entrez:
22
1
2019
Statut:
ppublish
Résumé
Chordoma is a primary bone cancer with no approved therapy
Identifiants
pubmed: 30664779
doi: 10.1038/s41591-018-0312-3
pii: 10.1038/s41591-018-0312-3
pmc: PMC6633917
mid: NIHMS1514494
doi:
Substances chimiques
Fetal Proteins
0
Protein Kinase Inhibitors
0
Small Molecule Libraries
0
T-Box Domain Proteins
0
Transcription Factors
0
Cyclin-Dependent Kinases
EC 2.7.11.22
Brachyury protein
EQ43SC3GDB
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
292-300Subventions
Organisme : NCI NIH HHS
ID : R01 CA215452
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA176152
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA176058
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008307
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA217848
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA190861
Pays : United States
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