Hepatitis D Virus-Specific CD8
Adult
CD8-Positive T-Lymphocytes
/ immunology
Cells, Cultured
Cytomegalovirus
/ immunology
Epitopes, T-Lymphocyte
Female
HLA-A Antigens
/ metabolism
HLA-B Antigens
/ metabolism
Hepatitis B virus
/ immunology
Hepatitis B, Chronic
/ immunology
Hepatitis D, Chronic
/ blood
Hepatitis Delta Virus
/ genetics
Hepatitis delta Antigens
/ immunology
Herpesvirus 4, Human
/ immunology
Humans
Immunologic Memory
/ immunology
Immunologic Surveillance
/ immunology
Influenza A virus
/ immunology
Interferon-gamma
/ metabolism
Interleukin-7 Receptor alpha Subunit
/ metabolism
Male
Middle Aged
Peptides
/ immunology
Phenotype
Programmed Cell Death 1 Receptor
/ metabolism
Young Adult
Lymphocyte
Mutation
Transcription Factor
Virus Escape
Journal
Gastroenterology
ISSN: 1528-0012
Titre abrégé: Gastroenterology
Pays: United States
ID NLM: 0374630
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
15
08
2018
revised:
08
01
2019
accepted:
15
01
2019
pubmed:
22
1
2019
medline:
14
5
2019
entrez:
22
1
2019
Statut:
ppublish
Résumé
Hepatitis D virus (HDV) superinfection of patients with chronic HBV infection results in rapid progression to liver cirrhosis. Little is known about HDV-specific T cells and how they contribute to the antiviral immune response and liver disease pathogenesis. We isolated peripheral blood mononuclear cells from 28 patients with chronic HDV and HBV infection, identified HDV-specific CD8 We identified 6 CD8 CD8
Sections du résumé
BACKGROUND & AIM
Hepatitis D virus (HDV) superinfection of patients with chronic HBV infection results in rapid progression to liver cirrhosis. Little is known about HDV-specific T cells and how they contribute to the antiviral immune response and liver disease pathogenesis.
METHODS
We isolated peripheral blood mononuclear cells from 28 patients with chronic HDV and HBV infection, identified HDV-specific CD8
RESULTS
We identified 6 CD8
CONCLUSIONS
CD8
Identifiants
pubmed: 30664876
pii: S0016-5085(19)30095-2
doi: 10.1053/j.gastro.2019.01.035
pmc: PMC7367679
mid: NIHMS1519072
pii:
doi:
Substances chimiques
Epitopes, T-Lymphocyte
0
HLA-A Antigens
0
HLA-B Antigens
0
Hepatitis delta Antigens
0
Interleukin-7 Receptor alpha Subunit
0
PDCD1 protein, human
0
Peptides
0
Programmed Cell Death 1 Receptor
0
Interferon-gamma
82115-62-6
Banques de données
ClinicalTrials.gov
['NCT02511431', 'NCT00023322', 'NCT01495585', 'NCT00001971']
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1805-1819.e9Subventions
Organisme : Intramural NIH HHS
ID : Z01 DK054509
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 DK054516
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA DK054508
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA DK054509
Pays : United States
Informations de copyright
Copyright © 2019 AGA Institute. Published by Elsevier Inc. All rights reserved.
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