Gut microbiota density influences host physiology and is shaped by host and microbial factors.
Adiposity
Adult
Aged
Aged, 80 and over
Animals
Clostridioides difficile
Clostridium Infections
/ microbiology
Crohn Disease
/ microbiology
Fecal Microbiota Transplantation
Female
Gastrointestinal Microbiome
Homeostasis
Humans
Ileum
/ microbiology
Immune System
Inflammatory Bowel Diseases
Male
Mice
Mice, Inbred C57BL
Microbiota
Middle Aged
Mucous Membrane
/ microbiology
Phenotype
RNA, Ribosomal, 16S
/ metabolism
Species Specificity
Young Adult
fecal microbiota transplantation
gut microbiome
human
human biology
infectious disease
inflammatory bowel disease
medicine
microbiology
microbiota density
mouse
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
22 01 2019
22 01 2019
Historique:
received:
28
07
2018
accepted:
04
01
2019
entrez:
23
1
2019
pubmed:
23
1
2019
medline:
19
5
2020
Statut:
epublish
Résumé
To identify factors that regulate gut microbiota density and the impact of varied microbiota density on health, we assayed this fundamental ecosystem property in fecal samples across mammals, human disease, and therapeutic interventions. Physiologic features of the host (carrying capacity) and the fitness of the gut microbiota shape microbiota density. Therapeutic manipulation of microbiota density in mice altered host metabolic and immune homeostasis. In humans, gut microbiota density was reduced in Crohn's disease, ulcerative colitis, and ileal pouch-anal anastomosis. The gut microbiota in recurrent This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter).
Identifiants
pubmed: 30666957
doi: 10.7554/eLife.40553
pii: 40553
pmc: PMC6342524
doi:
pii:
Substances chimiques
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : R01 CA161373
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK112679
Pays : United States
Organisme : NIH HHS
ID : S10 OD018522
Pays : United States
Organisme : NIGMS NIH HHS
ID : GM007280
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020541
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM108505
Pays : United States
Organisme : NIDDK NIH HHS
ID : F31 DK112679
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016087
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK110352
Pays : United States
Organisme : NIGMS NIH HHS
ID : GM108505
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI118610
Pays : United States
Informations de copyright
© 2019, Contijoch et al.
Déclaration de conflit d'intérêts
EC, GB, CY, IM, ZL, RN, SL, SH, CJ, KR, RB, ID, RH, SF, YL, NY, TL, PL, SL, IP, AG, JC, RK, SK, XQ, AC, AH, AA, JR, FF, MS, AN, PR, CR, SA, KS, LP, MS, KH, JZ, BZ, BL, HI, WS, AD, WW, BC, CD, DG, SI, AL, JM, EM, RU, SN, JN, BS, TU, PR, JG, PL, ST, JF, CB, SP, JC, JC, ES, CA, AK, BS No competing interests declared, RH, MD, JF Is a consultant for Janssen and has no other financial competing interests to declare.
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