The Crohn's disease polymorphism,

Alleles Animals Autophagy-Related Proteins / genetics Bacteroides Crohn Disease / genetics Dysbiosis / genetics Fecal Microbiota Transplantation Feces / microbiology Gastrointestinal Microbiome Gene Knock-In Techniques Genotype Humans Immune System Mice Polymorphism, Genetic Risk Th1 Cells / cytology Th17 Cells / cytology
ATG16L1T300A Bacteroides Bacteroides ovatus Crohn's Disease T cell gut immunology infectious disease inflammation microbiology mouse

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
22 01 2019
Historique:
received: 11 07 2018
accepted: 20 12 2018
entrez: 23 1 2019
pubmed: 23 1 2019
medline: 19 5 2020
Statut: epublish

Résumé

Inflammatory bowel disease (IBD) is driven by dysfunction between host genetics, the microbiota, and immune system. Knowledge gaps remain regarding how IBD genetic risk loci drive gut microbiota changes. The Crohn's disease risk allele

Identifiants

DOI: 10.7554/eLife.39982 PMID: 30666959 PMC: PMC6342529
pubmed: 30666959
doi: 10.7554/eLife.39982
pii: 39982
pmc: PMC6342529
doi:
pii:

Substances chimiques

Atg16l1 protein, mouse 0
Autophagy-Related Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIH HHS
ID : DK097485
Pays : United States
Organisme : NIH HHS
ID : DK105653
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK043351
Pays : United States
Organisme : NIDDK NIH HHS
ID : F31 DK105653
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK092405
Pays : United States
Organisme : NIH HHS
ID : CA154426
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK036836
Pays : United States
Organisme : NIH HHS
ID : DK110499
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA154426
Pays : United States
Organisme : Richard and Susan Smith Family Foundation
ID : Smith Family Foundation Award for Excellence in Biomedical Research
Pays : International
Organisme : NIH HHS
ID : DK092405
Pays : United States
Organisme : NIDDK NIH HHS
ID : R24 DK110499
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK097485
Pays : United States

Informations de copyright

© 2019, Lavoie et al.

Déclaration de conflit d'intérêts

SL, KC, KL, HJ, HP, EC, MM, JL, CG, JD, JG, HV, AA, AK, RX No competing interests declared, WG Senior editor, eLife

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Auteurs

Sydney Lavoie (S)

Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, United States.
Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, United States.
ORCID: 0000-0003-2890-3634

Kara L Conway (KL)

Gastrointestinal Unit, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, United States.

Kara G Lassen (KG)

Broad Institute of Harvard and MIT, Cambridge, United States.
Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, United States.
ORCID: 0000-0001-7023-461X

Humberto B Jijon (HB)

Gastrointestinal Unit, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, United States.

Hui Pan (H)

Joslin Diabetes Center, Boston, United States.

Eunyoung Chun (E)

Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, United States.
Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, United States.

Monia Michaud (M)

Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, United States.
Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, United States.

Jessica K Lang (JK)

Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, United States.
Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, United States.

Carey Ann Gallini Comeau (CA)

Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, United States.
Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, United States.

Jonathan M Dreyfuss (JM)

Joslin Diabetes Center, Boston, United States.

Jonathan N Glickman (JN)

Department of Pathology, Harvard Medical School, Boston, United States.
Beth Israel Deaconess Medical Center, Boston, United States.

Hera Vlamakis (H)

Broad Institute of Harvard and MIT, Cambridge, United States.

Ashwin Ananthakrishnan (A)

Gastrointestinal Unit, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, United States.

Aleksander Kostic (A)

Joslin Diabetes Center, Boston, United States.
Department of Microbiology and Immunobiology, Harvard Medical School, Boston, United States.

Wendy S Garrett (WS)

Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, United States.
Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, United States.
Broad Institute of Harvard and MIT, Cambridge, United States.
Department and Division of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, United States.
ORCID: 0000-0002-5092-0150

Ramnik J Xavier (RJ)

Gastrointestinal Unit, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, United States.
Broad Institute of Harvard and MIT, Cambridge, United States.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Allèles › The Crohn's disease polymorphism,
questionsmedicales.fr › Eucaryotes › Animaux › The Crohn's disease polymorphism,
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines associées à l'autophagie › The Crohn's disease polymorphism,
questionsmedicales.fr › Bactéries › Bactéries à Gram négatif › Bactéries anaérobies à Gram négatif › Bâtonnets à Gram négatif anaérobies droits, incurvés et spiralés › Bacteroidaceae › Bacteroides › The Crohn's disease polymorphism,
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies inflammatoires intestinales › Maladie de Crohn › The Crohn's disease polymorphism,
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Dysbiose › The Crohn's disease polymorphism,
questionsmedicales.fr › Thérapeutique › Biothérapie › Transplantation de microbiote fécal › The Crohn's disease polymorphism,
questionsmedicales.fr › Liquides et sécrétions biologiques › Fèces › The Crohn's disease polymorphism,
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › The Crohn's disease polymorphism,
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-in de gènes › The Crohn's disease polymorphism,
questionsmedicales.fr › Phénomènes génétiques › Génotype › The Crohn's disease polymorphism,
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Crohn's disease polymorphism,
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › The Crohn's disease polymorphism,
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The Crohn's disease polymorphism,
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › The Crohn's disease polymorphism,
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › The Crohn's disease polymorphism,
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Lymphocytes auxiliaires Th1 › The Crohn's disease polymorphism,
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Cellules Th17 › The Crohn's disease polymorphism,