The Effect of Psyllium Husk on Intestinal Microbiota in Constipated Patients and Healthy Controls.
constipation
ispaghula
microbiome
prebiotics
transit
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 Jan 2019
20 Jan 2019
Historique:
received:
17
12
2018
revised:
16
01
2019
accepted:
17
01
2019
entrez:
24
1
2019
pubmed:
24
1
2019
medline:
25
4
2019
Statut:
epublish
Résumé
Psyllium is a widely used treatment for constipation. It traps water in the intestine increasing stool water, easing defaecation and altering the colonic environment. We aimed to assess the impact of psyllium on faecal microbiota, whose key role in gut physiology is being increasingly recognised. We performed two randomised, placebo-controlled, double-blinded trials comparing 7 days of psyllium with a placebo (maltodextrin) in 8 healthy volunteers and 16 constipated patients respectively. We measured the patients' gastrointestnal (GI) transit, faecal water content, short-chain fatty acid (SCFA) and the stool microbiota composition. While psyllium supplement had a small but significant effect on the microbial composition of healthy adults (increasing
Identifiants
pubmed: 30669509
pii: ijms20020433
doi: 10.3390/ijms20020433
pmc: PMC6358997
pii:
doi:
Substances chimiques
Fatty Acids, Volatile
0
Psyllium
8063-16-9
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Academy of Finland
ID : 0313471-7
Organisme : Ironwood Pharmaceuticals Inc., Cambridge, MA, USA
ID : -
Références
Curr Microbiol. 1999 Oct;39(4):231-2
pubmed: 10486060
Microbiology. 2002 Jan;148(Pt 1):257-66
pubmed: 11782518
J Clin Gastroenterol. 2008 Sep;42 Suppl 3 Pt 2:S174-6
pubmed: 18685505
J Microbiol Methods. 2010 May;81(2):127-34
pubmed: 20171997
J Appl Microbiol. 2010 Dec;109(6):1946-56
pubmed: 21070516
Aliment Pharmacol Ther. 2011 Apr;33(8):895-901
pubmed: 21332763
World J Gastroenterol. 2011 Mar 28;17(12):1519-28
pubmed: 21472114
PLoS One. 2011;6(7):e23035
pubmed: 21829582
J Agric Food Chem. 2012 Feb 1;60(4):946-54
pubmed: 22224418
Physiol Rev. 2012 Apr;92(2):791-896
pubmed: 22535897
J Nutr. 2012 Jul;142(7):1259-65
pubmed: 22649263
Nature. 2012 Sep 13;489(7415):220-30
pubmed: 22972295
Nucleic Acids Res. 2013 Jan;41(Database issue):D590-6
pubmed: 23193283
World J Gastroenterol. 2012 Dec 28;18(48):7378-83
pubmed: 23326148
J Agric Food Chem. 2013 May 15;61(19):4614-21
pubmed: 23556460
FEMS Microbiol Ecol. 2013 Aug;85(2):376-88
pubmed: 23614882
BMC Gastroenterol. 2013 Jul 11;13:113
pubmed: 23844808
Nat Methods. 2013 Oct;10(10):996-8
pubmed: 23955772
Neurogastroenterol Motil. 2014 Feb;26(2):205-14
pubmed: 24165044
Gut. 2016 Mar;65(3):540-2
pubmed: 26276682
Gastroenterology. 2016 Feb;150(2):367-79.e1
pubmed: 26460205
Carbohydr Polym. 2016 Mar 30;139:159-66
pubmed: 26794959
Aliment Pharmacol Ther. 2016 Jul;44(1):35-44
pubmed: 27125883
Neurogastroenterol Motil. 2017 Jan;29(1):null
pubmed: 27477318
Front Microbiol. 2016 Oct 26;7:1706
pubmed: 27833600
Gut. 2017 Nov;66(11):1968-1974
pubmed: 28213610
Br J Pharmacol. 2017 Sep;174(17):2805-2817
pubmed: 28631296
Nutr Res. 2017 Aug;44:27-37
pubmed: 28821315
Exp Ther Med. 2017 Oct;14(4):3122-3126
pubmed: 28912861
Gastroenterology. 2018 Mar;154(4):1037-1046.e2
pubmed: 29174952
Best Pract Res Clin Gastroenterol. 2017 Dec;31(6):643-648
pubmed: 29566907
PLoS One. 2018 Jul 26;13(7):e0201410
pubmed: 30048547
Neurogastroenterol Motil. 2018 Sep;30(9):e13400
pubmed: 30062794
Front Microbiol. 2018 Jul 20;9:1618
pubmed: 30072976
Curr Opin Pharmacol. 2018 Dec;43:87-92
pubmed: 30219638