Various Evolutionary Trajectories Lead to Loss of the Tobramycin-Potentiating Activity of the Quorum-Sensing Inhibitor Baicalin Hydrate in
Anti-Bacterial Agents
/ pharmacology
Biofilms
/ drug effects
Burkholderia cenocepacia
/ drug effects
Drug Resistance, Bacterial
/ physiology
Drug Therapy, Combination
Enzyme Inhibitors
/ pharmacology
Flavonoids
/ pharmacology
Genome, Bacterial
/ genetics
Microbial Sensitivity Tests
Quorum Sensing
/ drug effects
Reactive Oxygen Species
/ metabolism
Tobramycin
/ pharmacology
Whole Genome Sequencing
Burkholderia
biofilms
evolution
quorum sensing
resistance
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
01
10
2018
accepted:
05
01
2019
pubmed:
24
1
2019
medline:
13
3
2020
entrez:
24
1
2019
Statut:
epublish
Résumé
Combining antibiotics with potentiators that increase their activity is a promising strategy to tackle infections caused by antibiotic-resistant bacteria. As potentiators do not interfere with essential processes, it has been hypothesized that they are less likely to induce resistance. However, evidence supporting this hypothesis is lacking. In the present study, we investigated whether
Identifiants
pubmed: 30670425
pii: AAC.02092-18
doi: 10.1128/AAC.02092-18
pmc: PMC6437513
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Enzyme Inhibitors
0
Flavonoids
0
Reactive Oxygen Species
0
baicalin
347Q89U4M5
Tobramycin
VZ8RRZ51VK
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 American Society for Microbiology.
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