An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning.
Animals
Exons
/ genetics
Fertility
Gene Expression Regulation, Developmental
Germ Cells
/ metabolism
Male
Meiosis
/ genetics
Metaphase
/ genetics
Mice, Inbred C57BL
Models, Animal
Organ Specificity
RNA Splice Sites
/ genetics
RNA Splicing
/ genetics
RNA-Binding Proteins
/ metabolism
Testis
/ metabolism
RNA
alternative splicing
chromosomes
gene expression
meiosis
mouse
retrogene
spermatogenesis
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
24 01 2019
24 01 2019
Historique:
received:
18
06
2018
accepted:
18
12
2018
entrez:
25
1
2019
pubmed:
25
1
2019
medline:
9
4
2020
Statut:
epublish
Résumé
Male germ cells of all placental mammals express an ancient nuclear RNA binding protein of unknown function called RBMXL2. Here we find that deletion of the retrogene encoding RBMXL2 blocks spermatogenesis. Transcriptome analyses of age-matched deletion mice show that RBMXL2 controls splicing patterns during meiosis. In particular, RBMXL2 represses the selection of aberrant splice sites and the insertion of cryptic and premature terminal exons. Our data suggest a
Identifiants
pubmed: 30674417
doi: 10.7554/eLife.39304
pii: 39304
pmc: PMC6345566
doi:
pii:
Substances chimiques
RNA Splice Sites
0
RNA-Binding Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : R01 AG046544
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00007/6
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_U127580973
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 089225/Z/09/Z
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P006612/1
Pays : United Kingdom
Organisme : NIH HHS
ID : R01 AG AG046544
Pays : United States
Informations de copyright
© 2019, Ehrmann et al.
Déclaration de conflit d'intérêts
IE, JC, MG, KJ, YL, SG, TC, Dd, JS, SC, IA, YB, DE No competing interests declared
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