A defined commensal consortium elicits CD8 T cells and anti-cancer immunity.
Adenocarcinoma
/ immunology
Animals
Antigens, CD
/ metabolism
Bacteria
/ classification
CD8-Positive T-Lymphocytes
/ cytology
Cell Line, Tumor
Dendritic Cells
/ immunology
Feces
/ microbiology
Female
Gastrointestinal Microbiome
/ immunology
Healthy Volunteers
Histocompatibility Antigens Class I
/ immunology
Humans
Integrin alpha Chains
/ metabolism
Interferon-gamma
/ biosynthesis
Listeria monocytogenes
/ immunology
Listeriosis
/ immunology
Male
Mice
Programmed Cell Death 1 Receptor
/ antagonists & inhibitors
Symbiosis
/ immunology
Xenograft Model Antitumor Assays
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
26
03
2018
accepted:
05
12
2018
pubmed:
25
1
2019
medline:
20
6
2019
entrez:
25
1
2019
Statut:
ppublish
Résumé
There is a growing appreciation for the importance of the gut microbiota as a therapeutic target in various diseases. However, there are only a handful of known commensal strains that can potentially be used to manipulate host physiological functions. Here we isolate a consortium of 11 bacterial strains from healthy human donor faeces that is capable of robustly inducing interferon-γ-producing CD8 T cells in the intestine. These 11 strains act together to mediate the induction without causing inflammation in a manner that is dependent on CD103
Identifiants
pubmed: 30675064
doi: 10.1038/s41586-019-0878-z
pii: 10.1038/s41586-019-0878-z
doi:
Substances chimiques
Antigens, CD
0
Histocompatibility Antigens Class I
0
Integrin alpha Chains
0
Programmed Cell Death 1 Receptor
0
alpha E integrins
0
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
600-605Subventions
Organisme : NIH HHS
ID : DK43351
Pays : United States
Organisme : NIH HHS
ID : AT009708
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : CommentIn